Evidence map›Paper›PMID 32154028›Full record

ArticleCardio-oncology (London, England)2020

Increased C-reactive protein is associated with the severity of thoracic radiotherapy-induced cardiomyopathy.

Justin M Canada, Georgia K Thomas, Cory R Trankle, Salvatore Carbone, Hayley Billingsley, Benjamin W Van Tassell, Ronald K Evans, Ryan Garten, Elisabeth Weiss, Antonio Abbate

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  10. NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful.Translational research : the journal of laboratory and clinical medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Justin M Canada *1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.ORCID 0000-0002-1342-7463
Georgia K Thomas *1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.
Cory R Trankle1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.
Salvatore Carbone1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.
Hayley Billingsley1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.
Benjamin W Van Tassell1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.
Ronald K Evans2Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Ryan Garten2Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Elisabeth Weiss4Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.
Antonio Abbate1VCU Pauley Heart Center, Virginia Commonwealth University, P.O. Box 980335, 1200 E. Broad Street, Richmond, Virginia, 23298 USA.
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
NCATS NIH HHS UL1 TR002649NCI NIH HHS P30 CA016059
6 · The paper itself

Abstract

backgroundIrradiation of the heart during cancer radiotherapy is associated with a dose-dependent risk of heart failure. Animal studies have demonstrated that irradiation leads to an inflammatory response within the heart as well as a reduction in cardiac reserve. In the current study we aimed to evaluate whether inflammatory biomarkers correlated with changes in cardiac function and reserve after radiotherapy for breast or lung cancer. METHODS AND

resultsWe studied 25 subjects with a history of breast or lung cancer without a prior diagnosis of cardiovascular disease or heart failure, 1.8 years [0.4-3.6] post-radiotherapy involving at least 5 Gray (Gy) to at least 10% of the heart. High-sensitivity C-reactive protein (CRP) was abnormal (≥2 mg/L) in 16 (64%) subjects. Cardiac function and reserve was measured with Doppler echocardiography before and after exercise and defined as left-ventricular ejection fraction (LVEF), early diastolic mitral annulus velocity (e'), and increase in LV outflow tract velocity time integral cardiac output (cardiac reserve) with exercise. Subjects with abnormal CRP had significantly lower LVEF (51 [44-59] % vs 61 [52-64] %,

conclusionElevated systemic inflammation is associated with impaired left-ventricular systolic and diastolic function both at rest and during exercise in subjects who have received radiotherapy with significant incidental heart dose for the treatment of cancer.

Indexed as

CardiotoxicityInflammationRadiotherapy

Identifiers

PMID32154028
PMCPMC7048115
OpenAlexW3011333788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.