ArticleCardio-oncology (London, England)2019
Antecedent cancer in Takotsubo syndrome predicts both cardiovascular and long-term mortality.
Article in Cardio-oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Clinical outcomes and left ventricular recovery in patients with solid malignancies developing Takotsubo syndrome: a retrospective cohort study.Archive of clinical cases · 2026Article
- When Is the Broken Heart Most Dangerous? Assessing Risk Factors to Predict Inpatient Death in Takotsubo Cardiomyopathy: Analysis of the National Inpatient Sample for 2021.Journal of the American Heart Association · 2025Article
- Clinical outcomes of takotsubo syndrome in patients with cancer: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- A contemporary update on cancer and takotsubo syndrome.Frontiers in cardiovascular medicine · 2023Review
- Cardiogenic shock among cancer patients.Frontiers in cardiovascular medicine · 2022Review
- Shining a light on perioperative Takotsubo syndrome.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTakotsubo syndrome (TTS), primarily an acute myocardial inflammatory condition engendered by catecholamine exposure, is associated with similar long-term mortality rates to those of patients with acute myocardial infarction. However, there is increasing evidence of a nexus between TTS and underlying malignancies:- many patients have antecedent cancer (A/Ca), while incremental risk of late cancer-related death has also been reported. PURPOSE: To evaluate potential interactions between A/Ca among TTS patients and both early and late clinical course.
methodsThree hundred forty-six consecutive TTS patients [aged 69 ± 13 (SD) years, males: 8.2%] were prospectively followed up for a median duration of 4.1 (IQR 2.2-6.4) years. Associations between A/Ca and severity of acute attacks, in-hospital complications and long-term death rates were sought utilising univariate analyses followed by multiple logistic regression analysis.
resultsA/Ca (present in 16.8% of patients) was associated with (i) greater elevation of hs-CRP and NT-proBNP concentrations (
conclusions(1) A/Ca is associated with greater clinical severity of initial TTS attacks and substantially greater long-term CVS-related as well as all-cause mortality.(2) Post-discharge therapy with either βBl or ACEi/ARB is associated with reductions in long-term mortality rates.Overall, the current data suggest operation of substantial interactions between neoplasia and TTS, both at the level of pathogenesis and of outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.