ReviewChemical science2020
Influenza as a molecular walker.
Review in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- 3D Single-Virus Tracking: Advances in Methodology and Labeling Strategies Towards Probing the Virus-Epithelium Interaction.Viruses · 2026Review
- Programming DNA machines to move.Nature reviews. Chemistry · 2026Review
- Discrete long-range on-cell motion of bacteriophage T4.Microbiology spectrum · 2026Article
- Sialic acids in infection and their potential use in detection and protection against pathogens.RSC chemical biology · 2024Review
- Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle.Nature communications · 2024Article
- A novel N95 respirator with chitosan nanoparticles: mechanical, antiviral, microbiological and cytotoxicity evaluations.Discover nano · 2023Article
- H3N2 influenza A virus gradually adapts to human-type receptor binding and entry specificity after the start of the 1968 pandemic.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Receptor Density-Dependent Motility of Influenza Virus Particles on Surface Gradients.ACS applied materials & interfaces · 2023Article
- Repeated influenza vaccination induces similar immune protection as first-time vaccination but with differing immune responses.Influenza and other respiratory viruses · 2023Article
- Capturing the start point of the virus-cell interaction with high-speed 3D single-virus tracking.Nature methods · 2022Article
- Single-virus assay reveals membrane determinants and mechanistic features of Sendai virus binding.Biophysical journal · 2022Article
- Virology from the perspective of theoretical colloid and interface science.Current opinion in colloid & interface science · 2021Review
- Multivalent Affinity Profiling: Direct Visualization of the Superselective Binding of Influenza Viruses.ACS nano · 2021Article
- Nucleic Acid-Based Sensing Techniques for Diagnostics and Surveillance of Influenza.Biosensors · 2021Review
- Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors.Science advances · 2021Article
- Virions and respiratory droplets in air: Diffusion, drift, and contact with the epithelium.Bio Systems · 2020Review
- Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action.Angewandte Chemie (International ed. in English) · 2020Article
- Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2020Article
- Interaction of the Amino-Terminal Domain of the ISAV Fusion Protein with a Cognate Cell Receptor.Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The surface of the influenza virus is decorated with the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving enzyme neuraminidase (NA). HA is responsible for host cell recognition, while NA prevents aggregation and entrapment, but the intricate mechanism of how the functions of these glycoproteins cooperate and how they are regulated by mutational responses to environmental pressures remains unclear. Recently, several groups have described the motion of influenza over surfaces and reported that this motion is inhibited by NA inhibitors. We argue that the motion of influenza resembles the motility of artificial receptor-cleaving particles called "molecular spiders". The cleaving of receptors by this type of molecular walkers leads to self-avoiding motion across a surface. When the binding and cleaving rates of molecular spiders are balanced, they move both rapidly and efficiently. The studies of molecular spiders offer new insights into the functional balance of HA and NA, but they do not address the asymmetric distribution of HA and NA on the surface of influenza. We propose that receptor-cleaving molecular walkers could play an important role in the further investigation of the motility of influenza viruses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.