Evidence map›Paper›PMID 32153563›Full record

ArticleFrontiers in immunology2020

Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs.

Alyson A Fiorillo, Christopher R Heier, Yu-Fang Huang, Christopher B Tully, Tanel Punga, Anna Rostedt Punga

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Circulating miRNAs drive personalized medicine based on subgroup classification in myasthenia gravis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  9. Review
  10. Review
  11. A microRNA Signature for the Diagnosis of Statins Intolerance.International journal of molecular sciences · 2022
    Article
  12. MicroRNA-regulated B cells in obesity.Immunometabolism (Cobham, Surrey) · 2022
    Review
  13. Effects ofAnimals : an open access journal from MDPI · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Epigenetic Regulations of AhR in the Aspect of Immunomodulation.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alyson A FiorilloCenter for Genetic Medicine Research, Children's Research Institute, Washington, DC, United States.
Christopher R HeierCenter for Genetic Medicine Research, Children's Research Institute, Washington, DC, United States.
Yu-Fang HuangDepartment of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.
Christopher B TullyCenter for Genetic Medicine Research, Children's Research Institute, Washington, DC, United States.
Tanel PungaDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Anna Rostedt PungaDepartment of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.
Uppsala University · SEGeorge Washington University · US

Funding

Mechanisms of anti-inflammation and membrane stabilization in muscular dystrophyR00HL130035 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI HEIER, CHRISTOPHER RYAN · 2017 to 2019
$730k
Mechanisms of anti-inflammation and membrane stabilization in muscular dystrophyK99HL130035 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI HEIER, CHRISTOPHER RYAN · 2015 to 2016
$191k
NHLBI NIH HHS K99 HL130035NHLBI NIH HHS R00 HL130035NIAMS NIH HHS L40 AR068727NIAMS NIH HHS L40 AR070539
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate important intracellular biological processes. In myasthenia gravis (MG), a disease-specific pattern of elevated circulating miRNAs has been found, and proposed as potential biomarkers. These elevated miRNAs include miR-150-5p, miR-21-5p, and miR-30e-5p in acetylcholine receptor antibody seropositive (AChR+) MG and miR-151a-3p, miR-423-5p, let-7a-5p, and let-7f-5p in muscle-specific tyrosine kinase antibody seropositive (MuSK+) MG. In this study, we examined the regulation of each of these miRNAs using chromatin immunoprecipitation sequencing (ChIP-seq) data from the Encyclopedia of DNA Elements (ENCODE) to gain insight into the transcription factor pathways that drive their expression in MG. Our aim was to look at the transcription factors that regulate miRNAs and then validate some of those

Indexed as

Gene Expression RegulationAdultAgedAged, 80 and overAnimalsAntibodiesCirculating MicroRNACohort StudiesFemaleForkhead Transcription FactorsHumansInterferon Regulatory FactorsMaleMiceMiddle AgedMyasthenia GravisAntibodiesCirculating MicroRNAForkhead Transcription FactorsInterferon Regulatory FactorsMUSK protein, humanReceptor Protein-Tyrosine KinasesReceptors, CholinergicReceptors, EstrogenRNA, MessengerSTAT Transcription FactorsestradiolFOXOmicroRNAmiR-21-5pmyasthenia gravisNF-κB

Identifiers

PMID32153563
PMCPMC7046803
OpenAlexW3006885479

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.