Evidence map›Paper›PMID 32153503›Full record

ReviewFrontiers in endocrinology2020

Metabolic Health, Insulin, and Breast Cancer: Why Oncologists Should Care About Insulin.

Lisa D Yee, Joanne E Mortimer, Rama Natarajan, Eric C Dietze, Victoria L Seewaldt

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 5 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  10. Breast Cancer and Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisa D YeeCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Joanne E MortimerCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Rama NatarajanCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Eric C DietzeCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Victoria L SeewaldtCity of Hope Comprehensive Cancer Center, Duarte, CA, United States.
City of Hope · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Inflammatory Gene Transcription In Diabetic ConditionsR01DK065073 · NIDDK · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI NATARAJAN, RAMA · 2003 to 2021
$7.9M
Diversity Supplement to Combined Breast MRI/Biomarker Strategies to Identify Aggressive BiologyU01CA189283 · NCI · DUKE UNIVERSITY · PI CLINTON, STEVEN K, MIRANDA-CARBONI, GUSTAVO ADOLFO · 2015 to 2020
$4.0M
Tension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9M
Mechanisms of breast cancer associated with obesityR01CA170851 · NCI · TUFTS UNIVERSITY BOSTON · PI KUPERWASSER, CHARLOTTE, SEEWALDT, VICTORIA L. · 2012 to 2015
$2.6M
KCNK9 Imprinting in Breast Cancer Progression and MetastasisR01CA155664 · NCI · DUKE UNIVERSITY · PI SEEWALDT, VICTORIA L. · 2011 to 2015
$1.8M
Targeted Chemoprevention of Breast Cancer: From the Bench to Clinical TestingR01CA158668 · NCI · DUKE UNIVERSITY · PI SEEWALDT, VICTORIA L. · 2012 to 2016
$1.7M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA155664NCI NIH HHS R01 CA158668NCI NIH HHS R01 CA170851NCI NIH HHS R01 CA192914NCI NIH HHS U01 CA189283NIDDK NIH HHS R01 DK065073
6 · The paper itself

Abstract

Studies investigating the potential link between adult pre-menopausal obesity [as measured by body mass index (BMI)] and triple-negative breast cancer have been inconsistent. Recent studies show that BMI is not an exact measure of metabolic health; individuals can be obese (BMI > 30 kg/m

Indexed as

Body Mass IndexBreast NeoplasmsFemaleHumansInsulinObesityOncologistsRisk FactorsInsulinbreast cancerinsulinmetabolic healthmetforminTNBC (Triple negative breast cancer)

Identifiers

PMID32153503
PMCPMC7045050
OpenAlexW3006689281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.