Evidence map›Paper›PMID 32153441›Full record

ArticleFrontiers in psychiatry2020

Possible Involvement of Tissue Plasminogen Activator/Brain-Derived Neurotrophic Factor Pathway in Anti-Depressant Effects of Electroacupuncture in Chronic Unpredictable Mild Stress-Induced Depression in Rats.

Tong Luo, Huiling Tian, Hongtao Song, Jun Zhao, Ai Liya, Yumin Fang, Junhui Mou, Zhigang Li, Saiyin Chaoketu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  15. Total Triterpenes ofFrontiers in pharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Tong LuoDepartment of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Huiling TianDepartment of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Hongtao SongDepartment of Traditional Chinese Medicine, Inner Mongolia People's Hospital, Hohhot, China.
Jun ZhaoDepartment of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Ai LiyaGraduate School, Inner Mongolia Medical University, Hohhot, China.
Yumin FangDepartment of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Junhui MouDepartment of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Zhigang LiDepartment of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Saiyin ChaoketuDepartment of Wu-Liao and Rehabilitation, Inner Mongolia International Mongolian Hospital, Hohhot, China.
Beijing University of Chinese Medicine · CNInner Mongolia International Mongolian Hospital · CNInner Mongolia Medical University · CNInner Mongolia People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUsing a rat model of chronic unpredictable mild stress (CUMS), to investigate the effects of electroacupuncture (EA) on the tissue plasminogen activator (tPA)/brain-derived neurotrophic factor (BDNF) pathway.

methodsSixty male Sprague-Dawley rats were randomly divided into four groups: normal, model, fluoxetine (fluox), or EA. Experimental groups were subjected to 28 d of CUMS modeling. One hour after CUMS, the fluox and EA groups were treated with fluox and a 20 min EA intervention, respectively. Depressive-like behaviors were assessed by open field and sucrose preference tests. After the rats were sacrificed, brains were dissected and processed using hematoxylin and eosin (HE) staining to observe changes in the morphology and quantity of neurons in the hippocampal

resultsCompared to the model group, the number of horizontal and vertical movements and the percentage of sucrose consumption in the EA groups were significantly increased (P < 0.01). Compared to the model group, HE staining showed that the hippocampal neurons in the EA and fluox groups were arranged neatly, with rich layers and complete cell structures. The Western blot and real-time PCR showed that the levels of tPA, BDNF, tropomyosin receptor kinase B, and BDNF micro RNA (mRNA) in the hippocampi of the EA group were higher than in the model group (P < 0.01, P < 0.01, P < 0.05, P < 0.01, respectively). The content of p75NTR, proBDNF, and tPA mRNA in the hippocampi of the EA group displayed no significant differences compared to the model group. The tPA mRNA content in the raphe nuclei of the EA group was higher than in the model group (P < 0.01), and the BDNF content in the raphe nuclei was lower than in the model group (P < 0.05). There were no significant differences in tPA and BDNF mRNA between the EA and model groups.

conclusionEA may reverse depressive-like behaviors in CUMS, which may be related to the tPA/BDNF pathway in the hippocampus.

Indexed as

BDNFdepressionelectroacupuncturehippocampusraphe nucleitPA

Identifiers

PMID32153441
PMCPMC7044269
OpenAlexW3008646871

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.