ArticleFrontiers in physiology2020
Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography.Intensive care medicine experimental · 2026Review
- A multi-fidelity poroelastic finite element and machine learning framework for characterizing respiratory mechanics in porcine lungs.Biomechanics and modeling in mechanobiology · 2026Article
- Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography.Intensive care medicine experimental · 2026Review
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Structural and functional characteristics of healthy and injured porcine lungs during deflation: a quantitative CT imaging analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.Journal of medical devices · 2025Article
- Regional ventilation dynamics of electrical impedance tomography validated with four-dimensional computed tomography: single-center, prospective, observational study.Critical care (London, England) · 2024Observational
- Imaging the Lung in ARDS: A Primer.Respiratory care · 2024Review
- Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection.Respiratory research · 2024Review
- Functional imaging for assessing regional lung ventilation in preclinical and clinical research.Frontiers in medicine · 2023Review
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange.Respiratory research · 2022Article
- Unshrinking the baby lung to calm the VILI vortex.Critical care (London, England) · 2022Review
- Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells.Frontiers in bioengineering and biotechnology · 2022Article
- The Physiological Basis of High-Frequency Oscillatory Ventilation and Current Evidence in Adults and Children: A Narrative Review.Frontiers in physiology · 2022Review
- Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography.Annals of biomedical engineering · 2021Article
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- Effects of Lung Injury on Regional Aeration and Expiratory Time Constants: Insights From Four-Dimensional Computed Tomography Image Registration.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Mechanical ventilation strategies that reduce the heterogeneity of regional lung stress and strain may reduce the risk of ventilator-induced lung injury (VILI). In this study, we used registration of four-dimensional computed tomographic (4DCT) images to assess regional lung aeration and deformation in 10 pigs under baseline conditions and following acute lung injury induced with oleic acid. CT images were obtained via dynamic axial imaging (Siemens SOMATOM Force) during conventional pressure-controlled mechanical ventilation (CMV), as well as high-frequency and multi-frequency oscillatory ventilation modalities (HFOV and MFOV, respectively). Our results demonstrate that oscillatory modalities reduce intratidal strain throughout the lung in comparison to conventional ventilation, as well as the spatial gradients of dynamic strain along the dorsal-ventral axis. Harmonic distortion of parenchymal deformation was observed during HFOV with a single discrete sinusoid delivered at the airway opening, suggesting inherent mechanical nonlinearity of the lung tissues. MFOV may therefore provide improved lung-protective ventilation by reducing strain magnitudes and spatial gradients of strain compared to either CMV or HFOV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.