Evidence map›Paper›PMID 32153404›Full record

ArticleFrontiers in pharmacology2020

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy

Xiaowei Sun, Dongyan Wang, Tingting Zhang, Xuejian Lu, Fangfang Duan, Lili Ju, Xiaotong Zhuang, Xicheng Jiang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaowei SunDepartment of Acupuncture and Moxibustion, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Dongyan WangDepartment of Acupuncture and Moxibustion, The Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Tingting ZhangDepartment of Integrated Chinese and Western Medicine, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Xuejian LuDepartment of Chinese Medicine Clinical Foundation, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
Fangfang DuanDepartment of Chinese Medicine Clinical Foundation, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
Lili JuDepartment of Chinese Medicine Clinical Foundation, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
Xiaotong ZhuangDepartment of Chinese Medicine Clinical Foundation, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
Xicheng JiangDepartment of Synopsis of the Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China.
Heilongjiang University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eugenol, as an active compound isolated from Acorus gramineus, has been shown to protect against cerebral ischemia-reperfusion (I/R) injury. Nonetheless, the detailed neuroprotective mechanisms of eugenol in cerebral I/R injury have not been elaborated. In the present study, cerebral I/R injury model was established by middle cerebral artery occlusion (MCAO) in rats. HT22 cells were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) to mimic cerebral I/R injury

Indexed as

AMPK/mTOR/P70S6K pathwayautophagycerebral I/R injuryeugenolHT 22

Identifiers

PMID32153404
PMCPMC7047211
OpenAlexW3007516526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.