Evidence map›Paper›PMID 32153400›Full record

ArticleFrontiers in pharmacology2020

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice.

Nigel Bush, Andrew Healey, Anant Shah, Gary Box, Vladimir Kirkin, Sue Eccles, Per Christian Sontum, Spiros Kotopoulis, Svein Kvåle, Annemieke van Wamel and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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  11. Acoustic Nanodrops for Biomedical Applications.Current opinion in colloid & interface science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Nigel BushJoint Department of Physics, Institute of Cancer Research, London, United Kingdom.
Andrew HealeyPhoenix Solutions AS, Oslo, Norway.
Anant ShahJoint Department of Physics, Institute of Cancer Research, London, United Kingdom.
Gary BoxDepartment of Physics, CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.
Vladimir KirkinDepartment of Physics, CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.
Sue EcclesDepartment of Physics, CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.
Per Christian SontumPhoenix Solutions AS, Oslo, Norway.
Spiros KotopoulisPhoenix Solutions AS, Oslo, Norway.
Svein KvålePhoenix Solutions AS, Oslo, Norway.
Annemieke van WamelNorwegian University of Science and Technology (NTNU), Trondheim, Norway.
Catharina de Lange DaviesNorwegian University of Science and Technology (NTNU), Trondheim, Norway.
Jeffrey BamberJoint Department of Physics, Institute of Cancer Research, London, United Kingdom.
Institute of Cancer Research · GBNorwegian University of Science and Technology · NO

Funding

Cancer Research UK 16464
6 · The paper itself

Abstract

introductionAcoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug (

methodsIn this study we investigated the therapeutic efficacy of ACT with liposomal doxorubicin for the treatment of triple negative breast cancer using orthotopic human tumor xenografts (MDA-MB-231-H.luc) in athymic mice (ICR-NCr-Foxn1

resultsResults show that combination with ACT induces a strong increase in the therapeutic efficacy of Doxil

Indexed as

acoustic cluster therapybreast cancerdoxorubicindrug deliverymicrobubblesultrasound

Identifiers

PMID32153400
PMCPMC7044119
OpenAlexW3008914777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.