ReviewFrontiers in neuroscience2020
Mechanisms Linking Olfactory Impairment and Risk of Mortality.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 46 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation of Preoperative Olfactory Identification Function With Preoperative Frailty and With Postoperative Complications and Mortality Following Elective Surgery
Correlation of Preoperative Global Olfactory Function With Frailty, Preoperative Cognitive Status, Postoperative Neurocognitive Disorders and Mortality Following Elective Surgery
Smell in Covid-19 and Efficacy of Nasal Theophylline
Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial)
Smell in COVID-19 and Efficacy of Nasal Theophylline 3
Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Olfactory dysfunction and all-cause mortality: a systematic review and meta-analysis.Journal of global health · 2026Pooled it
- Olfactory Impairment and Incident Cognitive Decline: A Systematic Review and Meta-Analysis.International forum of allergy & rhinology · 2025Pooled it
- Association of Olfactory Impairment With All-Cause Mortality: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2022Pooled it
- Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients.The Laryngoscope · 2021Pooled it
- Treatment of post-viral olfactory dysfunction: an evidence-based review with recommendations.International forum of allergy & rhinology · 2020Pooled it
- Partial Middle Turbinate Resection Versus Preservation on Olfactory Function: A Systematic Review and Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialePooled it
- Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2022Trial
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- Utility of the Questionnaire of Olfactory Disorders-Negative Statements in Age-Related Olfactory Dysfunction.American journal of rhinology & allergy · 2026Article
- Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026Review
- Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026Review
- Moving Beyond Odor Identification: Defining Olfactory Subdomain Cutoffs in Frailty Risk Assessment.International forum of allergy & rhinology · 2025Article
- An unexpected insight into the cause of olfactory dysfunction: fibrillogenesis of odorant-binding proteins.Cell death discovery · 2025Review
- Olfactory impairment associated with reduced physical capacity 24 months after COVID-19.Brain, behavior, & immunity - health · 2025Article
- A Randomized Controlled Trial on the Management of Post-COVID-19 Olfactory Dysfunction in a Pediatric Population.Cureus · 2025Article
- Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy.Frontiers in allergy · 2025Article
- Global Poorer Olfaction, Frailty and Postoperative Adverse Outcomes: Exploring Their Interplay in a Prospective Cohort of Older Adults Undergoing Elective Surgery.Clinical interventions in aging · 2025Article
- The association between olfactory subdomains and frailty: A prospective case‒control study investigation.International forum of allergy & rhinology · 2024Article
- Olfactory dysfunction as an early predictor for post-COVID condition at 1-year follow-up.Brain and behavior · 2024Article
- Correlations between Gustatory, Olfactory, Cognitive Function, and Age in Healthy Women.Nutrients · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfaction is a sense involved in a complex set of tasks, influencing eating behavior, increasing awareness of environmental hazards and affecting social communication. Surprisingly, smell disorders are very frequent, especially in the elderly population. Several recent studies conducted mostly in older subjects have demonstrated a strong association between olfactory impairment and overall mortality risk, with anosmia being even more predictive of 5 years mortality risk than cardiovascular disease. Presently, the underlying pathophysiology linking olfactory impairment to mortality remains unknown and only putative mechanisms are suggested. This review aims to examine the link between olfactory impairment and mortality and to discuss existing ideas on underlying existing mechanisms including, (1) the effect of olfactory loss on nutrition, life-threatening situations and social interactions, (2) associated neurodegenerative diseases, (3) accelerated brain aging, and (4) reflection of general health status being reflected in olfactory function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.