Evidence map›Paper›PMID 32153309›Full record

ArticleTrends in analytical chemistry : TRAC2020

Preserving Single Cells in Space and Time for Analytical Assays.

Luke A Gallion, Matthew M Anttila, David H Abraham, Angela Proctor, Nancy L Allbritton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in analytical chemistry : TRAC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luke A GallionDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
Matthew M AnttilaDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
David H AbrahamDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
Angela ProctorDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
Nancy L AllbrittonDepartment of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USNorth Carolina State University · US

Funding

MICROFABRICATED INSTRUMENTATION TO MEASURE SPHINGOLIPID SIGNALING IN HUMAN ACUTE MYELOID LEUKEMIAR01CA233811 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L., ARMISTEAD, PAUL MICHAEL · 2019 to 2023
$3.1M
PROFILING SIGNALING ACTIVITY AND GENE EXPRESSION IN SINGLE, PANCREATIC ADENOCARCINOMA CELLS USING CE-RNA-SEQR01CA224763 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L., LAWRENCE, DAVID S. · 2018 to 2022
$2.9M
A Novel Class of Enzyme Sensors to Elucidate the Biochemical Responses of Human Nasal Epithelial Cells to Heavy MetalsF31HL147500 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTTILA, MATTHEW M · 2019 to 2021
$79k
Development of an Ultrasensitive Microdevice for the Investigation of Sphingosine Kinase Activity in Single CellsF31CA243312 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLION, LUKE AUSTIN · 2019 to 2021
$78k
NCI NIH HHS F31 CA243312NCI NIH HHS R01 CA224763NCI NIH HHS R01 CA233811NHLBI NIH HHS F31 HL147500
6 · The paper itself

Abstract

Analytical assays performed within clinical laboratories influence roughly 70% of all medical decisions by facilitating disease detection, diagnosis, and management. Both in clinical and academic research laboratories, single-cell assays permit measurement of cell diversity and identification of rare cells, both of which are important in the understanding of disease pathogenesis. For clinically utility, the single-cell assays must be compatible with the clinical workflow steps of sample collection, sample transportation, pre-analysis processing, and single-cell assay; therefore, it is paramount to preserve cells in a state that resembles that

Indexed as

analytical chemistrybioanalytical chemistryclinical assaysfixationlaboratory medicinepreservationsample preparationsignalingsingle-cell analysis

Identifiers

PMID32153309
PMCPMC7061724
OpenAlexW2986116707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.