Evidence map›Paper›PMID 32153113›Full record

Observational studyInfluenza and other respiratory viruses2020

Burden of respiratory viral infection in persons with human immunodeficiency virus.

Subhashini A Sellers, Kenton L Dover, Aubrey G Bailey, Avery Cheves, Anthony B Eason, Elena B Popowitch, Melissa B Miller, David A Wohl, Dirk P Dittmer, William A Fischer

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Influenza and other respiratory viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Subhashini A SellersDivision of Pulmonary and Critical Care Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-2852-4634
Kenton L DoverDivision of Pulmonary and Critical Care Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Aubrey G BaileyDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Avery ChevesDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Anthony B EasonDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-6723-7999
Elena B PopowitchUNC Hospitals, McClendon Clinical Laboratories, Chapel Hill, North Carolina.
Melissa B MillerDepartment of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
David A WohlDivision of Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Dirk P DittmerDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
William A FischerDivision of Pulmonary and Critical Care Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
University of North Carolina at Chapel Hill · USUniversity of North Carolina Health Care · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
TRAINING IN RESPIRATORY AND ENVIRONMENTAL MEDICINET32HL007106 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES, DOERSCHUK, CLAIRE M · 1985 to 2021
$7.3M
ART Modulation of Viral Pathogenesis in Oral EpitheliaR01DE018304 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DITTMER, DIRK P · 2007 to 2025
$6.9M
Mentoring New Investigators in Criminal Justice HIV Prevention and TreatmentK24DA037101 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOHL, DAVID A · 2014 to 2018
$911k
Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus DiseaseK23AI121516 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM · 2016 to 2019
$783k
NHLBI NIH HHS T32 HL007106NHLBI NIH HHS T32HL007106NIAID NIH HHS K23 AI121516NIAID NIH HHS P30 AI050410NIDA NIH HHS K24 DA037101NIDA NIH HHS K24DA037101NIDCR NIH HHS R01 DE018304NIDCR NIH HHS R01-DE018304-09NIH HHS 2-R01-DE018304-09NIH HHS K23AI121516NIH HHS K24DA037101NIH HHS T32HL007106
6 · The paper itself

Abstract

This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real-time reverse transcription polymerase chain reaction and primer-independent next-generation sequencing (NGS). Of 82 subjects, respiratory viruses were the most common pathogen identified in 27 (33%), followed by fungus and bacteria in 8 (10%) and 4 (5%) subjects, respectively. Among subjects with RVI, 11 (41%) required ICU admission and 16 (59%) required mechanical ventilation. The proportion of respiratory viruses identified, and the associated complicated hospital course highlights the significant role that RVIs play in the lung health of PLH.

Indexed as

High-Throughput Nucleotide SequencingCost of IllnessFemaleHIVHIV InfectionsHospitalizationHumansMaleMiddle AgedPneumonia, ViralPrevalenceProspective StudiesRespiratory Tract InfectionsTertiary Care CentersVirusesacquired immune deficiency syndromehuman immunodeficiency virusnext-generation sequencingrespiratory virusviral pneumonia

Identifiers

PMID32153113
PMCPMC7298306
OpenAlexW3012168671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.