Evidence map›Paper›PMID 32152951›Full record

ArticleJournal of mammary gland biology and neoplasia2020

Inter-Individual Variation in Response to Estrogen in Human Breast Explants.

Karen A Dunphy, Amye L Black, Amy L Roberts, Aman Sharma, Zida Li, Sneha Suresh, Eva P Browne, Kathleen F Arcaro, Jennifer Ser-Dolansky, Carol Bigelow and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mammary gland biology and neoplasia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. A novel preclinical model of the normal human breast.Journal of mammary gland biology and neoplasia · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Antibody Validation for Estrogen Receptor Beta.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Karen A DunphyThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA. kdunphy@vasci.umass.edu.ORCID 0000-0002-3761-6197
Amye L BlackThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Amy L RobertsThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Aman SharmaThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Zida LiThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Sneha SureshThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Eva P BrowneThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Kathleen F ArcaroThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Jennifer Ser-DolanskyPioneer Valley Life Sciences, Springfield, MA, USA.
Carol BigelowDepartment of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA.
Melissa A TroesterDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sallie S SchneiderThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Grace Makari-JudsonDivision of Hematology-Oncology, University of Massachusetts Medical School/Baystate, Springfield, MA, USA.
Giovanna M CrisiDepartment of Pathology, University of Massachusetts Medical School/Baystate, Springfield, MA, USA.
D Joseph JerryThe Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
University of Massachusetts Amherst · USPioneer (United States) · USBaystate Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Metabolomics Administrative Supplement: Disruption of parity-induced tumor suppressor pathways by xenoestrogen exposures during pregnancyU01ES026140 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI JERRY, D. JOSEPH, SCHNEIDER, SALLIE SMITH · 2015 to 2019
$3.7M
P53-dependent responses to toxicants in parous and nulliparous breastR01ES015739 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI JERRY, D. JOSEPH · 2007 to 2010
$1.5M
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES015739NIEHS NIH HHS U01 ES026140
6 · The paper itself

Abstract

Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as rodent models have demonstrated variability in estrogen sensitivity. Our objective was to determine individual variation in expression of estrogen receptor (ER) and estrogen-induced responses in the normal human breast. Human breast tissue from female donors undergoing reduction mammoplasty surgery were collected for microarray analysis of ER expression. To examine estrogen-induced responses, breast tissue from 23 female donors were cultured ex- vivo in basal or 10 nM 17β-estradiol (E2) media for 4 days. Expression of ER genes (ESR1 and ESR2) increased significantly with age. E2 induced consistent increases in global gene transcription, but expression of target genes AREG, PGR, and TGFβ2 increased significantly only in explants from nulliparous women. E2-treatment did not induce consistent changes in proliferation or radiation induced apoptosis. Responses to estrogen are highly variable among women and not associated with levels of ER expression, suggesting differences in intracellular signaling among individuals. The differences in sensitivity to E2-stimulated responses may contribute to variation in risk of breast cancer.

Indexed as

AdolescentAdultAgedApoptosisBiomarkers, TumorBreast NeoplasmsCell ProliferationEstrogensFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedPrognosisReceptors, EstrogenTumor Cells, CulturedYoung AdultBiomarkers, TumorEstrogensReceptors, EstrogenEstrogen receptorEstrogen signalingHuman breast explants

Identifiers

PMID32152951
PMCPMC7147970
OpenAlexW3010551324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.