Evidence map›Paper›PMID 32152908›Full record

ArticleJournal of assisted reproduction and genetics2020

Spatial and temporal changes in the expression of steroid hormone receptors in mouse model of endometriosis.

Anuradha Mishra, Mosami Galvankar, Neha Singh, Deepak Modi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Endometriosis: Challenges in Clinical Molecular Diagnostics and Treatment.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Role of HOXA10 in pathologies of the endometrium.Reviews in endocrine & metabolic disorders · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anuradha Mishra *Molecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India.
Mosami Galvankar *Molecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India.
Neha SinghMolecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India.
Deepak ModiMolecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India. deepaknmodi@yahoo.com.ORCID http://orcid.org/0000-0002-4230-4219
National Institute for Research in Reproductive Health · IN

Funding

Council of Scientific and Industrial Research, India SRFDepartment of Biotechnology , Ministry of Science and Technology BT/OR6587/MED/30/886/2012Indian Council of Medical Research ICMR-PDF 6th batchIndian Council of Medical Research SRFScience and Engineering Research Board SR/SO/HS-0277/2012
6 · The paper itself

Abstract

purposeEndometriosis is recognized as a steroid hormone-dependent disorder. However, controversies exist regarding the status of the steroid hormone receptor expression in endometriotic tissues. The purpose of this study was to determine the ontogeny of cellular changes in the expression of estrogen receptors (ERα, ERβ), G protein-coupled estrogen receptor 1 (GPER1), and progesterone receptors (PRs) in endometriosis using a mouse model.

methodsWe used the autologous uterine tissue transfer mouse model and studied the mRNA and protein expression of ERα, ERβ, GPER1, and PR in ectopic lesions at 2, 4, and 8 weeks of induction of endometriosis.

resultAs compared to endometrium of controls, in the ectopic endometrium, ERα is reduced while ERβ was elevated in stromal cells; however, Gper1 and PR levels are reduced in both stromal and epithelial cells in a time-specific manner. There is a high inter-animal variation in the levels of these receptors in ectopic endometrium as compared to controls; the levels also varied by almost 100-fold within the same lesion resulting in "micro-heterogeneity." The expression of all these receptors also deferred between two lesions from the same animal.

conclusionIn the endometriotic tissue, there is extensive inter-animal and intra-lesion heterogeneity in the expression of ERα, ERβ, GPER1, and PR. These changes are not due to the influence of the peritoneal environment but appear to be tissue intrinsic. We propose that the variable outcomes in hormonal therapy for endometriosis could be possibly due to heterogeneity in the expression of steroid hormone receptors in the ectopic endometrium.

Indexed as

AnimalsDisease Models, AnimalEndometriosisEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression Regulation, DevelopmentalGonadal Steroid HormonesHumansMiceReceptors, EstrogenReceptors, G-Protein-CoupledReceptors, ProgesteroneEsr1 protein, mouseEstrogen Receptor alphaEstrogen Receptor betaGonadal Steroid HormonesGPER1 protein, mouseReceptors, EstrogenReceptors, G-Protein-CoupledReceptors, ProgesteroneEndometriosisEstrogen receptorGPER1HeterogeneityMouseProgesterone receptorSteroid hormone receptors

Identifiers

PMID32152908
PMCPMC7300172
OpenAlexW3010144211

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.