Evidence map›Paper›PMID 32152769›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2020

Myosin-XVa Controls Both Staircase Architecture and Diameter Gradation of Stereocilia Rows in the Auditory Hair Cell Bundles.

Shadan Hadi, Andrew J Alexander, A Catalina Vélez-Ortega, Gregory I Frolenkov

Open access · greenAbstract read
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Myosin motors in sensory hair bundle assembly.Current opinion in cell biology · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Dimensions of a Living Cochlear Hair Bundle.Frontiers in cell and developmental biology · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shadan HadiDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Andrew J AlexanderDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.
A Catalina Vélez-OrtegaDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA.ORCID 0000-0001-9157-8390
Gregory I FrolenkovDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. Gregory.Frolenkov@uky.edu.ORCID 0000-0002-9810-5024
University of Kentucky · US

Funding

Repair of mechano-electrical transduction in mammalian auditory hair cellsR01DC014658 · NIDCD · UNIVERSITY OF KENTUCKY · PI FROLENKOV, GREGORY I · 2015 to 2019
$2.0M
Graduate Training in Integrative PhysiologyT32GM118292 · NIGMS · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S · 2017 to 2021
$999k
High-Pressure Freezing / Freeze-Substitution SystemS10OD025130 · OD · UNIVERSITY OF KENTUCKY · PI FROLENKOV, GREGORY I · 2018 to 2018
$294k
NIDCD NIH HHS R01 DC014658NIGMS NIH HHS T32 GM118292NIH HHS S10 OD025130
6 · The paper itself

Abstract

Mammalian hair cells develop their mechanosensory bundles through consecutive phases of stereocilia elongation, thickening, and retraction of supernumerary stereocilia. Many molecules involved in stereocilia elongation have been identified, including myosin-XVa. Significantly less is known about molecular mechanisms of stereocilia thickening and retraction. Here, we used scanning electron microscopy (SEM) to quantify postnatal changes in number and diameters of the auditory hair cell stereocilia in shaker-2 mice (Myo15

Indexed as

ActinsAnimalsHair Cells, Auditory, InnerHair Cells, Auditory, OuterMiceMice, KnockoutMyosinsProtein IsoformsStereociliaActinsMyo15 protein, mouseMyosinsProtein Isoformsdevelopmenthearingmechanotransductionnon-syndromic congenital deafness DFNB3shaker-2 mouse

Identifiers

PMID32152769
PMCPMC7271090
OpenAlexW3011209960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.