SynthesisEuropean radiology2020
Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis.
Synthesis in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Spectral CT and Photon-counting Detector CT: Principles and Applications in Neuroradiology.Radiology. Imaging cancer · 2026Review
- Review
- CT-based texture analysis for preoperative prediction of key histopathological features in laryngeal cancer.Polish journal of radiology · 2026Article
- Analysis of clinical efficacy and quality of life in hypopharyngeal cancer patients undergoing laryngeal-preserving surgery.Frontiers in oncology · 2026Article
- Diagnostic value, sensitivity and specificity of CT, MRI, and PET in evaluation of cartilage invasion in laryngeal and hypopharyngeal cancer.Scientific reports · 2025Article
- Head-to-head comparison of [European journal of nuclear medicine and molecular imaging · 2025Article
- Time-Intensity Curve Analysis of Contrast-Enhanced Ultrasound for Non-Ossified Thyroid Cartilage Invasion in Laryngeal Squamous Cell Carcinoma.Tomography (Ann Arbor, Mich.) · 2025Article
- Primary Site Influences the Ability of Magnetic Resonance Imaging to Assess Cartilage Invasion in Advanced Laryngeal Cancer.The Laryngoscope · 2025Article
- Head and Neck Squamous Cell Carcinoma: Insights from Dual-Energy Computed Tomography (DECT).Tomography (Ann Arbor, Mich.) · 2024Review
- Time-Saving 3D MR Imaging Protocols with Millimeter and Submillimeter Isotropic Spatial Resolution for Face and Neck Imaging as Implemented at a Single-Site Major Referral Center.AJNR. American journal of neuroradiology · 2024Article
- The Diagnostic Value of CEUS in Assessing Non-Ossified Thyroid Cartilage Invasion in Patients with Laryngeal Squamous Cell Carcinoma.Journal of clinical medicine · 2024Article
- CT of the Larynx: Is an Additional High-Resolution Acquisition Necessary for Diagnostic Accuracy?AJNR. American journal of neuroradiology · 2023Article
- Imaging for Laryngeal Malignancies: Guidelines for Clinicians.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- The Multimodal Diagnostic Approach Necessary in Detecting Elusive Submucosal Laryngeal Cancer.Cureus · 2023Article
- Twenty questions from the surgeon to the radiologist to better plan an open partial horizontal laryngectomy.Frontiers in oncology · 2023Review
- Prognostic value of computed tomography scan detection of cartilage invasion in advanced laryngeal cancer treated with primary total laryngectomy.Head & neck · 2022Article
- Undifferentiated Small Round Cell Sarcoma of the Postcricoid Region of the Hypopharynx: A Rare Case Report and Review of the Literature.OncoTargets and therapy · 2021Article
- Article
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Authors and funding
10 authors.
Funding
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Abstract
objectiveTo compare the diagnostic performance of contrast-enhanced CT with that of MRI in the detection of cartilage invasion in patients with laryngo-hypopharyngeal cancer.
methodsA systematic literature search in the Ovid-MEDLINE and EMBASE databases was performed for studies reporting diagnostic accuracy of CT and/or MRI in detecting cartilage invasion from laryngo-hypopharyngeal cancer between 2000 and 2018. The pooled sensitivity and specificity, and their 95% confidence intervals were calculated for CT and MRI using bivariate random effects modeling. Subgroup and meta-regression analyses were performed. Indirect comparison was also performed by univariable meta-regression.
resultFourteen articles including 776 patients were included in the systematic review and meta-analysis: eight for CT, and six for MRI. CT and MRI showed pooled sensitivities of 66% (95% CI, 49-80%) and 88% (95% CI, 79-93%), and pooled specificities of 90% (95% CI, 82-94%) and 81% (95% CI, 76-84%), respectively. MRI showed significantly higher sensitivity than CT (p = 0.02). The specificities showed no statistically significant difference between CT and MRI (p = 0.39). The CT studies showed heterogeneity and a threshold effect, while MRI showed neither heterogeneity nor threshold effect. In the meta-regression analysis for CT, the type of cartilage analyzed (thyroid only vs. thyroid/cricoid/arytenoid, p < 0.001) was a significant factor influencing the heterogeneity in the diagnostic performance of the CT studies.
conclusionsIn conclusion, MRI has significantly higher sensitivity than CT for detecting cartilage invasion in patients with laryngo-hypopharyngeal cancer, without a significant difference in the specificity. KEY POINTS: • MRI has significantly higher sensitivity than CT for detecting cartilage invasion in patients with laryngo-hypopharyngeal cancer.
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