Evidence map›Paper›PMID 32152732›Full record

Observational studyHeart and vessels2020

Clinical impact of statin therapy on vasospastic angina: data from a Korea nation-wide cohort study.

Won-Woo Seo, Sang-Ho Jo, Sung Eun Kim, Seung Hwan Han, Kwan Yong Lee, Sung Ho Her, Min-Ho Lee, Sung Seek Cho, Sang Hong Baek

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Pharmacotherapy in patients with vasomotor disorders.International journal of cardiology. Heart & vasculature · 2023
    Review
  5. Management of Coronary Artery Spasm.European cardiology · 2023
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Won-Woo SeoDepartment of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
Sang-Ho JoDivision of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896, Pyeongchon-dong, Dongan-gu, Anyang-si, Gyeonggi-do, 431-070, South Korea. sophi5neo@gmail.com.
Sung Eun KimDepartment of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
Seung Hwan HanDepartment of Cardiovascular Medicine, Gil Medical Center, Gachon University, Incheon, South Korea.
Kwan Yong LeeDepartment of Cardiovascular Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, South Korea.
Sung Ho HerDepartment of Cardiovascular Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, South Korea.
Min-Ho LeeDepartment of Cardiovascular Medicine, Soon Chun Hyang Seoul Hospital, Seoul, South Korea.
Sung Seek ChoDepartment of Epidemiology and Occupational Medicine, College of Medicine, Dong-A University, Busan, South Korea.
Sang Hong BaekDepartment of Cardiovascular Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Catholic University of Korea · KRDong-A University · KRGachon University Gil Medical Center · KRHallym University · KRHallym University Sacred Heart Hospital · KRKangdong Sacred Heart Hospital · KRThe Catholic University of Korea Incheon St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of statin therapy on reducing adverse cardiovascular events in vasospastic angina (VSA) has been inconsistent. Therefore, we investigated the association between statin therapy and adverse cardiovascular events in a large, prospective VSA cohort. The Variant Angina Korea registry consecutively enrolled 2960 patients suspected VSA. Among them, we included 1713 patients who were diagnosed with VSA based on coronary provocation test. We divided the patients into the statin (n = 744) and no-statin group (n = 914) according to the medication prescribed at discharge. The primary outcome was a composite of cardiac death, acute coronary syndrome, and new-onset life-threatening arrhythmia during a 3-year follow-up period. The primary outcome occurred in 32 patients (4.3%) in the statin and 28 patients (3.1%) in the no-statin group. In Kaplan-Meier analysis before and after propensity score matching, there was no significant difference in the cumulative incidence of primary outcomes between both groups. Multivariate Cox regression analysis demonstrated that the focal type of VSA was independent predictor of primary outcomes, but statin therapy was not. Furthermore, the lack of benefit of statin therapy for primary outcomes was consistently observed across the statin intensity and spasm characteristics. In conclusion, the present study demonstrated that statin therapy did not reduce adverse cardiovascular events in patients with VSA.

Indexed as

Acute Coronary SyndromeAdultAgedAngina PectorisArrhythmias, CardiacCoronary VasospasmFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedProspective StudiesRegistriesRepublic of KoreaRisk AssessmentHydroxymethylglutaryl-CoA Reductase InhibitorsCoronary angiographyKoreaStatinsVariant angina pectoris

Identifiers

PMID32152732
OpenAlexW3009356877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.