ArticleEuropean biophysics journal : EBJ2020
NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus.
Article in European biophysics journal : EBJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Expression of translation elongation factor P in Kocuria rhizophila is regulated by an inducible weak promoter.BMC microbiology · 2026Article
- The origins and evolution of translation factors.Trends in genetics : TIG · 2025Review
- EF-P and its paralog EfpL (YeiP) differentially control translation of proline-containing sequences.Nature communications · 2024Article
- Posttranslational modification of Elongation Factor P from Staphylococcus aureus.FEBS open bio · 2020Article
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15 authors at 4 institutions in 3 countries.
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Abstract
Elongation factor P (EF-P) is a translation protein factor that plays an important role in specialized translation of consecutive proline amino acid motifs. EF-P is an essential protein for cell fitness in native environmental conditions. It regulates synthesis of proteins involved in bacterial motility, environmental adaptation and bacterial virulence, thus making EF-P a potential drug target. In the present study, we determined the solution and crystal structure of EF-P from the pathogenic bacteria Staphylococcus aureus at 1.48 Å resolution. The structure can serve as a platform for structure-based drug design of novel antibiotics to combat the growing antibiotic resistance of S. aureus.
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