Trial reportEuropean journal of clinical nutrition2020
Intermittent versus continuous tube feeding in patients with hemorrhagic stroke: a randomized controlled clinical trial.
Trial report in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07353658 (The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke: An Exploratory Study
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- European stroke organisation guideline on stroke-associated pneumonia.European stroke journal · 2026Guideline
- Intermittent versus continuous enteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Intermittent enteral nutrition may increase gastrointestinal complications and mortality in critically ill patients.Frontiers in nutrition · 2025Pooled it
- Improving the Outcome of Brain-Injured Patients by Non-Continuous Feeding to Prevent Dysbiosis.Nutrients · 2026Review
- Interruptions of enteral nutrition in intensive care units: mechanisms, clinical impacts, and precision nursing interventions-a scoping review.Frontiers in nutrition · 2026Review
- Feeding time index and mortality in intensive care stroke patients: an exploratory cohort study.Turkish journal of medical sciences · 2026Observational
- Effects of enteral nutrition in stroke: an updated review.Frontiers in nutrition · 2025Review
- Article
- Bolus Versus Continuous Enteral Feeding for Critically Ill Patients: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Research trends in nutritional interventions for stroke: a bibliometric analysis and literature review.Frontiers in nutrition · 2024Article
- The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials.Frontiers in nutrition · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe arguments about whether intermittent or continuous tube feeding was preferred in patients with hemorrhagic stroke exist yet. This study aimed to examine the effects of intermittent versus continuous tube feeding on its intolerance performance and efficiency of calorie intake.
methodA convenience sample was selected from January 2018 to January 2019 in the Neurosurgery Department of West China Hospital, Sichuan Province. The participants were randomly allocated to either intermittent or continuous tube feeding group, fed four times or 24 h a day using electric feeding pump, respectively. The incidence of the intolerance and calorie intake were recorded and analyzed.
results78 patients took part in this study: 40 in the intermittent group and 38 in the continuous group. The incidence of the diarrhea was significantly lower in the continuous group (7.9 vs 37.5%, p = 0.002). The total intolerance rate was significantly lower in the continuous group compared with the intermittent group (63.2 vs 85.0%, p = 0.027). There was no significant difference in calorie intake between the intermittent and continuous group during the first 3 days (2595.4 ± 394.5 kcal vs 2317.8 ± 645.1 kcal, p = 0.099). No significant difference in total calorie intake was found between two groups (6265.6 ± 1261.3 kcal vs 6429.4 ± 1452.4 kcal, p = 0.597).
conclusionContinuous tube feeding was an effective way to improve the tolerance of enteral nutrition. But no enough evidence was found to support the advantage in calorie intake of continuous tube feeding in this study.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.