ArticleNature immunology2020
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer.
Abstract read
In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 271 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed, 2 pooled it
19.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
271 citing papers in PubMed, 2 syntheses or guidelines pooled it, 386 citations in OpenAlex.
- The Role of PD-L1 Expression as a Predictive Biomarker in Esophageal Cancer: a Meta-Analysis.Journal of gastrointestinal cancer · 2026Pooled it
- Therapeutic and immunomodulatory effects of Bojungikki-tang on cancer: a scoping review.BMC cancer · 2024Pooled it
- Transarterial chemoembolization plus atezolizumab and bevacizumab in patients with intermediate hepatocellular carcinoma: a single-arm, phase 2 trial.Signal transduction and targeted therapy · 2025Trial
- Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL.Nature · 2022Trial
- A PD-L1 Nanobody-Engineered Synthetic RNA Virus Enhances Hepatocellular Carcinoma Immunotherapy by Interfering PCSK9 and Upregulating MHC-I.Exploration (Beijing, China) · 2026Article
- Observation on the Surgical Efficacy of Neoadjuvant Immunotherapy Combined with Chemotherapy for Locally Advanced Hypopharyngeal Cancer.Annals of surgical oncology · 2026Article
- PD-1 regulates CD4Nature communications · 2026Article
- T cell-nanodrug conjugates synchronize vascular normalization and immune activation for solid tumor therapy.Science advances · 2026Article
- The dual role of Ganoderma lucidum polysaccharides in cancer treatment: Meridian tropism-based direct inhibition and immune-mediated modulation.Journal of the Chinese Medical Association : JCMA · 2026Review
- Bibliometric analysis of programmed death ligand-1 positron emission tomography probe research: development, landscape, and technological evolution.Nuclear medicine communications · 2026Article
- Spatial co-expression and cell-cell communication inference from spatially resolved transcriptomics with CONCISE.bioRxiv : the preprint server for biology · 2026Article
- Extracellular vesicles mediate intercellular transfer of PD-L1 and bystander T-cell suppression.Cellular and molecular life sciences : CMLS · 2026Article
- Immune modulatory vaccines targeting tumor microenvironment antigens: recent advances in oncology and beyond.Signal transduction and targeted therapy · 2026Review
- A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity.Nature biomedical engineering · 2026Article
- Neoadjuvant mFOLFOX6 plus camrelizumab and apatinib in colon cancer and biomarker research via spatiotemporal-omics profiling.NPJ precision oncology · 2026Article
- Engineered CD40-biosensor-expressing Treg cells as a cell therapy approach for inflammatory diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Antibody-dependent cellular phagocytosis in cancer immunotherapy: research and perspectives.Journal of translational medicine · 2026Review
- Strategies to target PD-1/PD-L1 in the tumor microenvironment.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Immune escape mechanisms and therapeutic advances in virus-associated hematological malignancies.Blood cancer journal · 2026Review
- PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function.Cell reports · 2026Article
211 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 1 institution in 1 country.
Brian DiskinS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Salma AdamS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Marcelo F CassiniS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Gustavo SanchezS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Miguel LiriaS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Berk AykutS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Chandan ButtarS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Eric LiS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Belen SundbergS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Ruben D SalasS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Ruonan ChenS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Junjie WangS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Mirhee KimS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Mohammad Saad FarooqS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Susanna NguyDepartment of Radiation Oncology, New York University School of Medicine, New York, NY, USA.
Carmine FedeleDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Kwan Ho TangDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Ting ChenDepartment of Pathology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1725-7956
Wei WangS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Mautin HundeyinS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Juan A Kochen RossiS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Emma KurzS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Muhammad Israr Ul HaqS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Jason KarlenS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Emma KrugerS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Zennur SekendizS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Dongling WuS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Sorin A A ShadaloeyS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Gillian BaptisteS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Gregor WerbaS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
Shanmugapriya SelvarajDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Cynthia LoomisDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Kwok-Kin WongDepartment of Medicine, New York University School of Medicine, New York, NY, USA.
Joshua LeinwandS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA.
George MillerS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, NY, USA. george.miller@nyumc.org.ORCID http://orcid.org/0000-0001-8482-4100
New York University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death protein 1 (PD-1) ligation delimits immunogenic responses in T cells. However, the consequences of programmed cell death 1 ligand 1 (PD-L1) ligation in T cells are uncertain. We found that T cell expression of PD-L1 in cancer was regulated by tumor antigen and sterile inflammatory cues. PD-L1
Indexed as
AnimalsB7-H1 AntigenCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell Line, TumorFemaleHumansImmune ToleranceInterferon-gammaMacrophagesMaleMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorSelf ToleranceB7-H1 AntigenInterferon-gammaProgrammed Cell Death 1 Receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.