Trial reportJournal of perinatology : official journal of the California Perinatal Association2020
Blinded randomized crossover trial: Skin-to-skin care vs. sucrose for preterm neonatal pain.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Assessment of cortisol as a neonatal pain biomarker in the application of non-pharmacological analgesia therapies: systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Sucrose analgesia for heel-lance procedures in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Non-pharmacological management of infant and young child procedural pain.The Cochrane database of systematic reviews · 2023Pooled it
- Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Kangaroo Care for Relieving Neonatal Pain Caused by Invasive Procedures: A Systematic Review and Meta-Analysis.Computational intelligence and neuroscience · 2022Pooled it
- Impact of skin-to-skin contact on acute procedural pain in newborns: a systematic review and meta-analysis.Jornal de pediatriaPooled it
- Trial
- Effectiveness of Sucrose Versus Breast Milk as Non-Pharmacological Measures in the Management of Neonatal Pain: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- An Effect of Smelled Breast Milk During and After Venous Blood Drawing on Newborn Infants' Pain and Comfort Level.Healthcare (Basel, Switzerland) · 2025Article
- Skin-to-skin contact-An effective intervention on pain and stress reduction in preterm infants.Frontiers in pediatrics · 2023Article
- Assessment and Management of Pain in Preterm Infants: A Practice Update.Children (Basel, Switzerland) · 2022Review
- Skin-to-Skin Care by Mother vs. Father for Preterm Neonatal Pain: A Randomized Control Trial (ENVIRON Trial).International journal of pediatrics · 2021Article
- State of the Art in Parent-Delivered Pain-Relieving Interventions in Neonatal Care: A Scoping Review.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare skin-to-skin care (SSC) and oral sucrose for preterm neonatal pain control.
methodsPreterm neonates (28-36 weeks gestation) requiring heel-stick were eligible. In group-A, SSC was given 15-min before first heel-stick, and sucrose was given 2-min before second heel-stick. In group-B, the sequence was reversed. Blinded premature infant pain profile (PIPP) score assessment was done at 0, 1, and 5-min of heel-stick by two assessors.
resultsA hundred neonates were enrolled. The inter-rater agreement for the PIPP score was good. The behavior state component was significantly lower in the sucrose group at all assessment points. The mean (SD) difference between 1-min and 0 min was similar [SSC 3.58(3.16) vs. sucrose 4.09(3.82), p = 0.24] between groups. The PIPP score attained baseline values at 5-min in both groups.
conclusionAlbeit sucrose indicated instantaneous action, SSC and sucrose have comparable clinical efficacy for preterm neonatal pain control. Multisensory stimulation with SSC may result in a higher behavioral state component of the PIPP score.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.