Evidence map›Paper›PMID 32152482›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2020

Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A.

Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda and 39 more

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Vascular function: a key player in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  5. Article
  6. Article
  7. Annual reports on hypertension research 2020.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
  8. Article
  9. Estimating local arterial stiffness using mixed-effects model-based residuals: a novel approach.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Tatsuya MaruhashiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Junko SogaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Noritaka FujimuraDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Naomi IdeiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shinsuke MikamiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yumiko IwamotoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Akimichi IwamotoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Masato KajikawaDivision of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Takeshi MatsumotoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Nozomu OdaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shinji KishimotoDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Shogo MatsuiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Haruki HashimotoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yuji TakaekoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takayuki YamajiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takahiro HaradaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yiming HanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yoshiki AibaraDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Farina Mohamad YusoffDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Takayuki HidakaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yasuki KiharaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kazuaki ChayamaDepartment of Gastroenterology and Metabolism, Biomedical Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kensuke NomaDivision of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Ayumu NakashimaDepartment of Stem Cell Biology and Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan.
Chikara GotoDepartment of Rehabilitation, Faculty of General Rehabilitation, Hiroshima International University, Hiroshima, Japan.
Hirofumi TomiyamaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Bonpei TakaseDivision of Biomedical Engineering, National Defense Medical College Research Institute, Tokorozawa, Japan.
Takahide KohroDivision of Cardiovascular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan.
Toru SuzukiDivision of Cardiovascular Medicine, University of Leicester, Leicester, UK.
Tomoko IshizuCardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Shinichiro UedaDepartment of Clinical Pharmacology and Therapeutics, School of Medicine, University of the Ryukyu, Okinawa, Japan.
Tsutomu YamazakiClinical Research Support Center, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Tomoo FurumotoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Kazuomi KarioDivision of Cardiovascular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan.
Teruo InoueDepartment of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan.
Shinji KobaDepartment of Medicine, Division of Cardiology, School of Medicine, Showa University, Tokyo, Japan.
Kentaro WatanabeDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), School of Medicine, Yamagata University, Yamagata, Japan.
Yasuhiko TakemotoDepartment of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Takuzo HanoDepartment of Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University, Wakayama, Japan.
Masataka SataDepartment of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Yutaka IshibashiDepartment of General Medicine, Faculty of Medicine, Shimane University, Izumo, Japan.
Koichi NodeDepartment of Cardiovascular and Renal Medicine, Saga University, Saga, Japan.
Koji MaemuraDepartment of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yusuke OhyaThe Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan.
Taiji FurukawaDepartment of Internal Medicine, School of Medicine, Teikyo University, Tokyo, Japan.
Hiroshi ItoDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Hisao IkedaFaculty of Fukuoka Medical Technology, Teikyo University, Omuta, Japan.
Akira YamashinaDepartment of Rehabilitation, Faculty of General Rehabilitation, Hiroshima International University, Hiroshima, Japan.
Yukihito HigashiDivision of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan. yhigashi@hiroshima-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The usefulness of brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, is not fully known for the management of treated hypertensive patients with a history of coronary artery disease (CAD) who have blood pressure less than 130/80 mmHg, a recommended blood pressure target in the updated major hypertension guidelines. We analyzed data for 447 treated hypertensive patients with CAD enrolled in FMD-J Study A for assessment of the predictive value of baPWV for future cardiovascular events. The primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow-up period of 47.6 months, the primary outcome occurred in 64 patients. Blood pressure less than 130/80 mmHg was significantly associated with a lower risk of the composite outcome independent of other cardiovascular risk factors in treated hypertensive patients with CAD (hazard ratio, 0.59; 95% confidence interval (CI), 0.35-0.99; P = 0.04). In treated hypertensive patients with CAD who had blood pressure less than 130/80 mmHg, baPWV above the cutoff value of 1731 cm/s, derived from receiver-operator characteristic curve analysis for the composite outcome was significantly associated with a higher risk of the composite outcome independent of conventional risk factors (hazard ratio, 2.83; 95% CI, 1.02-7.91; P = 0.04). baPWV was an independent predictor of cardiovascular events in treated hypertensive patients with CAD who had blood pressure less than 130/80 mmHg, for whom measurement of baPWV is recommended for cardiovascular risk assessment.

Indexed as

AgedAnkle Brachial IndexBlood PressureCardiovascular DiseasesCoronary Artery DiseaseFemaleHeart Disease Risk FactorsHumansHypertensionJapanMaleMiddle AgedPulse Wave AnalysisRisk AssessmentVascular StiffnessVasodilationArterial stiffnessBlood pressureBrachial–ankle pulse wave velocityCoronary artery diseaseHypertension

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.