ArticleScientific reports2020
NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Identification of new overlapping and disease-specific genetic risk factors for rheumatoid arthritis and radiographic axial spondyloarthritis: a meta-analysis of three large European populations and functional characterization.Frontiers in immunology · 2026Pooled it
- Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization.International journal of cancer · 2025Pooled it
- Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.International journal of molecular sciences · 2023Pooled it
- Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.Frontiers in immunology · 2021Pooled it
- The genetic puzzle of rheumatoid arthritis: Causes, progression, and treatment.Biochemistry and biophysics reports · 2025Review
- The interaction between a leflunomide-response methylation site (cg17330251) and variant (rs705379) on response to leflunomide in patients with rheumatoid arthritis.Frontiers in pharmacology · 2025Article
- Ovol1/2 loss-induced epidermal defects elicit skin immune activation and alter global metabolism.EMBO reports · 2023Article
- Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search.Rheumatology (Oxford, England) · 2022Review
- Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis.Antioxidants (Basel, Switzerland) · 2022Review
- Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil.BioMed research international · 2022Article
- Utility of Baseline Transcriptomic Analysis of Rheumatoid Arthritis Synovium as an Indicator for Long-Term Clinical Outcomes.Frontiers in medicine · 2022Article
- Genetic Predictors of Response to Acupuncture or Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: An Exploratory Analysis.Journal of pain and symptom management · 2021Article
- Article
- Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model.Bioinformatics advances · 2021Article
- Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Frontiers in immunology · 2021Review
- Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium.Blood cancer journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 16 institutions in 7 countries.
Jose Manuel Sánchez-MaldonadoGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Manuel Martínez-BuenoArea of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.
Helena CanhãoCEDOC, EpiDoC Unit, NOVA Medical School and National School of Public Health, Universidade Nova de Lisboa, Lisbon, Portugal.
Rob Ter HorstDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-0576-5873
Sonia Muñoz-PeñaGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Ana Moñiz-DíezGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Ana Rodríguez-RamosGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.ORCID http://orcid.org/0000-0003-3422-2886
Alejandro EscuderoRheumatology department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain.
Signe B SorensenFocused research unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, DK-6200, Aabenraa, Denmark.ORCID http://orcid.org/0000-0003-3215-1236
Merete L HetlandThe DANBIO registry, The Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology ad Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
Miguel A FerrerRheumatology department, Virgen de las Nieves University Hospital, Granada, Spain.
Bente GlintborgThe DANBIO registry, The Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology ad Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
Ileana FilipescuRheumatology department, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Eva Pérez-PampinRheumatology Unit, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Pablo Conesa-ZamoraClinical Analysis department, Santa Lucía University Hospital, Cartagena, Spain.
Antonio GarcíaRheumatology department, Virgen de las Nieves University Hospital, Granada, Spain.
Alfons den BroederRadboud university medical center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands.
Salvatore De VitaDepartment of Medical Area, Clinic of Rheumatology, University of Udine, Udine, Italy.
Svend Erik Hove JacobsenDepartment of Biochemistry and Immunology. University Hospital of Southern Jutland, Jutland, Denmark.
Eduardo CollantesRheumatology department, Reina Sofía Hospital/IMIBIC/University of Córdoba, Córdoba, Spain.
Luca QuartuccioDepartment of Medical Area, Clinic of Rheumatology, University of Udine, Udine, Italy.ORCID http://orcid.org/0000-0002-0134-6439
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-2421-6052
Yang LiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
João E FonsecaRheumatology and Metabolic Bone Diseases Department, Hospital de Santa Maria, CHLN, Lisbon, Portugal.
Manuel JuradoGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Miguel Ángel López-NevotInstituto de Investigación Biosanataria IBs.Granada, Granada, Spain.
Marieke J H CoenenRadboud university medical center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands.
Vibeke AndersenFocused research unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, DK-6200, Aabenraa, Denmark.
Rafael CálizGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
Juan SainzGenomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain. juan.sainz@genyo.es.ORCID http://orcid.org/0000-0002-9355-2423
Instituto de Investigación Biosanitaria de Granada · ESPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESRadboud University Nijmegen · NLHospital Universitario Virgen de las Nieves · ESInstituto Maimónides de Investigación Biomédica de Córdoba · ESUniversity of Copenhagen · DKUniversity of Southern Denmark · DKUniversity of Udine · ITIuliu Hațieganu University of Medicine and Pharmacy · ROSanta Lucía University General Hospital · ESSygehus Sønderjylland · DKUniversidade de Santiago de Compostela · ESUniversidade Nova de Lisboa · PTUniversity Medical Center Groningen · NLUniversity of Bonn · DEUniversity of Lisbon · PT
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy controls. The association of potentially interesting markers was validated with data from the DANBIO (695 RA patients and 978 healthy controls) and DREAM (882 RA patients) registries. The meta-analysis of our data with those from the DANBIO registry confirmed that anti-citrullinated protein antibodies (ACPA)-positive subjects carrying the NFKB2
Indexed as
Polymorphism, Single NucleotideArthritis, RheumatoidBiomarkersCase-Control StudiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedNF-kappa B p52 SubunitPrognosisRisk FactorsTumor Necrosis Factor InhibitorsBiomarkersNF-kappa B p52 SubunitNFKB2 protein, humanTumor Necrosis Factor Inhibitors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.