Evidence map›Paper›PMID 32152477›Full record

ArticleNature chemistry2020

A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates.

Penghui Zhang, Di Gao, Keli An, Qi Shen, Chen Wang, Yuchao Zhang, Xiaoshu Pan, Xigao Chen, Yifan Lyv, Cheng Cui and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  13. DNA-based nanostructures for RNA delivery.Medical review (2021) · 2024
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  17. Chemical science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Penghui Zhang *The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China.ORCID http://orcid.org/0000-0002-6512-1511
Di Gao *State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Keli An *The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China.
Qi ShenState Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Chen WangState Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Yuchao ZhangState Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Xiaoshu PanCenter for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Xigao ChenCenter for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Yifan LyvCenter for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Cheng CuiCenter for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Tingxizi LiangState Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Xiaoman DuanThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China.
Jie LiuThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China.
Tielin YangThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China.
Xiaoxiao HuMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, China.
Jun-Jie ZhuState Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. jjzhu@nju.edu.cn.ORCID http://orcid.org/0000-0002-8201-1285
Feng XuThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China. fengxu@mail.xjtu.edu.cn.
Weihong TanInstitute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. tan@hnu.edu.cn.ORCID http://orcid.org/0000-0002-8066-1524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathological markers as part of clinical therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this 'plug and play' platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy.

Indexed as

AnilidesAnimalsAntineoplastic AgentsCell Line, TumorCisplatinDrug CarriersDrug LiberationFemaleGlutathioneHumansHydrogen PeroxideLogicMice, NudeNanoparticlesPolyethylene GlycolsPolyethyleneimineAnilidesAntineoplastic AgentscabozantinibCisplatinDrug CarriersGlutathioneHydrogen PeroxidePolyethylene GlycolsPolyethyleneiminePyridinesRNA, Small Interfering

Identifiers

PMID32152477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.