ArticleScientific reports2020
Three-dimensional observation and analysis of remineralization in dentinal caries lesions.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Radiographic biomarkers on grayscale gradient transition zone improve differentiation of deep caries/reversible pulpitis and chronic pulpitis through diagnostic model analysis.Oral radiology · 2025Article
- Influence of Parotid Saliva Composition on Phosphate Species' Chemical State in Relation to Dental Caries.Clinical and experimental dental research · 2025Article
- The Ways of Forming and the Erosion/Decay/Aging of Bioapatites in the Context of the Reversibility of Apatites.International journal of molecular sciences · 2024Article
- A Study of the Association between Primary Oral Pathologies (Dental Caries and Periodontal Diseases) Using Synchrotron Molecular FTIR Spectroscopy in View of the Patient's Personalized Clinical Picture (Demographics and Anamnesis).International journal of molecular sciences · 2024Article
- Mineralization of Dentinal Lesions with Different Concentrations of Fluoride.International journal of dentistry · 2024Article
- Investigating salivary concentration of calcium ion in hypothyroidism.Health science reports · 2023Article
- The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study.Odontology · 2022Article
- Article
- Dental tissue remineralization by bioactive calcium phosphate nanoparticles formulations.Scientific reports · 2022Article
- Super high-quality SEM/FIB imaging of dentine structures without collagen fiber loss through a metal staining process.Scientific reports · 2022Article
- Functional signaturesJournal of oral microbiology · 2022Article
- Efficacy of a Novel Bioactive Glass-Polymer Composite for Enamel Remineralization following Erosive Challenge.International journal of dentistry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in the caries lesions were characterized by transmission electron microscopy (TEM), along with chemical element mapping using energy-dispersive spectroscopy (EDS)-STEM. FIB-SEM 3D reconstructions revealed a severely damaged dentin surface abundantly covered by bacteria. Although the dentin tubules were clogged up to a depth of 100 μm, bacterial invasion into dentin tubules was not observed. TEM crystal analysis and EDS-STEM revealed the presence of Ca and P, as well as of Mg within the HAp crystals deposited inside the dentin tubules. It was concluded that extensive remineralization with deposition of Mg-HAp crystals had occurred in dentin tubules of caries-arrested dentin. Understanding the natural remineralization process is thought to be helpful for developing clinical biomimetic remineralization protocols.
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