Evidence map›Paper›PMID 32152307›Full record

ArticleNature communications2020

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs.

Jiaxing Gong, Carl C L Schuurmans, Anne Metje van Genderen, Xia Cao, Wanlu Li, Feng Cheng, Jacqueline Jialu He, Arturo López, Valentin Huerta, Jennifer Manríquez and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jiaxing Gong *Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-6454-5956
Carl C L Schuurmans *Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-7614-0144
Anne Metje van GenderenDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Xia CaoDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-7451-0466
Wanlu LiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Feng ChengDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-4555-554X
Jacqueline Jialu HeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-6522-365X
Arturo LópezDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-2359-0202
Valentin HuertaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Jennifer ManríquezDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-6564-3208
Ruiquan LiDepartment of Surgery-Transplant and Holland Regenerative Medicine Program, University of Nebraska Medical Center, 985965 Nebraska Medical Center, Omaha, NE, 68198, USA.
Hongbin LiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-6127-9007
Clément DelavauxDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Shikha SebastianDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-7288-0447
Pamela E CapendaleDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Huiming WangThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, P. R. China.
Jingwei XieDepartment of Surgery-Transplant and Holland Regenerative Medicine Program, University of Nebraska Medical Center, 985965 Nebraska Medical Center, Omaha, NE, 68198, USA.
Mengfei YuThe Affiliated Stomatology Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, P. R. China.
Rosalinde MasereeuwDepartment of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3508, TB, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-1560-1074
Tina VermondenDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Science for Life, Utrecht University, Universiteitsweg 99, 3508, TB, Utrecht, The Netherlands. T.Vermonden@uu.nl.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139, USA. yszhang@research.bwh.harvard.edu.ORCID http://orcid.org/0000-0002-0045-0808

Funding

High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer TherapyR00CA201603 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2019 to 2021
$747k
Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor ModelsR21EB025270 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2018 to 2020
$726k
Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating FunctionsR21EB026175 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2018 to 2019
$468k
Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer TherapyK99CA201603 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2016 to 2017
$356k
NCI NIH HHS K99 CA201603NCI NIH HHS R00 CA201603NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB025270NIBIB NIH HHS R21 EB026175
6 · The paper itself

Abstract

Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.

Indexed as

Biomechanical PhenomenaPrinting, Three-DimensionalAnimalsBiocompatible MaterialsBioprintingChitosanGelatinHumansHydrogelsMCF-7 CellsMethacrylatesMicePolymersTissue EngineeringTissue ScaffoldsBiocompatible MaterialsChitosanGelatinHydrogelsMethacrylatesPolymers

Identifiers

PMID32152307
PMCPMC7062888

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.