ArticleNature communications2020
Nanocrystal facet modulation to enhance transferrin binding and cellular delivery.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Adsorption Energy Difference-Driven Synthesis of Perovskite Single Crystals With Tailored Exposed Facets.Angewandte Chemie (International ed. in English) · 2026Article
- Crystal Facet-Polysaccharide Matching in CFS-P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- New insights in nanocrystal technology chemotherapeutic drugs targeting cancer with a translational research paradigm.American journal of translational research · 2025Review
- Let the two sides of the same coin meet-Environmental health and safety-oriented development of functional nanomaterials for environmental remediations.Eco-Environment & Health · 2024Review
- Review
- Recent Advances in Simulation Studies on the Protein Corona.Pharmaceutics · 2024Review
- Protein Corona Formation on Cadmium-Bearing Nanoparticles: Important Role of Facet-Dependent Binding of Cysteine-Rich Proteins.Environment & health (Washington, D.C.) · 2024Article
- Bi-Functionalized Transferrin@MoSMaterials (Basel, Switzerland) · 2023Article
- Electrostatic-induced green and precise growth of model catalysts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Electrochemical Signal Amplification Strategies and Their Use in Olfactory and Taste Evaluation.Biosensors · 2022Review
- Drug Nanocrystals for Active Tumor-Targeted Drug Delivery.Pharmaceutics · 2022Review
- Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery.AAPS PharmSciTech · 2021Review
- Facet-Dependent Surface Charge and Hydration of Semiconducting Nanoparticles at Variable pH.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Importance of Surface Topography in Both Biological Activity and Catalysis of Nanomaterials: Can Catalysis by Design Guide Safe by Design?International journal of molecular sciences · 2021Review
- Inherited and acquired corona of coronavirus in the host: Inspiration from the biomolecular corona of nanoparticles.Nano today · 2021Article
- Molecular Modeling of Protein Corona Formation and Its Interactions with Nanoparticles and Cell Membranes for Nanomedicine Applications.Pharmaceutics · 2021Review
- Interfacial interactions of SERS-active noble metal nanostructures with functional ligands for diagnostic analysis of protein cancer markers.Mikrochimica acta · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Binding of biomolecules to crystal surfaces is critical for effective biological applications of crystalline nanomaterials. Here, we present the modulation of exposed crystal facets as a feasible approach to enhance specific nanocrystal-biomolecule associations for improving cellular targeting and nanomaterial uptake. We demonstrate that facet-engineering significantly enhances transferrin binding to cadmium chalcogenide nanocrystals and their subsequent delivery into cancer cells, mediated by transferrin receptors, in a complex biological matrix. Competitive adsorption experiments coupled with theoretical calculations reveal that the (100) facet of cadmoselite and (002) facet of greenockite preferentially bind with transferrin via inner-sphere thiol complexation. Molecular dynamics simulation infers that facet-dependent transferrin binding is also induced by the differential affinity of crystal facets to water molecules in the first solvation shell, which affects access to exposed facets. Overall, this research underlines the promise of facet engineering to improve the efficacy of crystalline nanomaterials in biological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.