Evidence map›Paper›PMID 32152201›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Noncoding Microdeletion in Mouse

Robert J Morell, Rafal Olszewski, Risa Tona, Samuel Leitess, Talah T Wafa, Ian Taukulis, Julie M Schultz, Elizabeth J Thomason, Keri Richards, Brittany N Whitley and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. A Systematic Review of Genes Affecting Endocochlear Potential.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Pooled it
  2. Pooled it
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  4. The Cochlear Lateral Wall as a Biological Battery: the Mechanisms Underlying KJournal of the Association for Research in Otolaryngology : JARO · 2026
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  16. Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Robert J MorellGenomics and Computational Biology Core.
Rafal OlszewskiAuditory Development and Restoration Program.
Risa TonaLaboratory of Molecular Genetics.
Samuel LeitessGenomics and Computational Biology Core.
Talah T WafaMouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892.
Ian TaukulisAuditory Development and Restoration Program.
Julie M SchultzLaboratory of Molecular Genetics.
Elizabeth J ThomasonLaboratory of Molecular Genetics.
Keri RichardsGenomics and Computational Biology Core.ORCID 0000-0001-8851-8864
Brittany N WhitleyLaboratory of Molecular Genetics.
Connor HillGenomics and Computational Biology Core.
Thomas SaundersTransgenic Animal Model Core, University of Michigan, Ann Arbor, Michigan 48109-5674.ORCID 0000-0003-2015-101X
Matthew F StarostDivision of Veterinarian Resources, National Institutes of Health, Maryland 20892, and.
Tracy FitzgeraldMouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892.
Elizabeth WilsonLaboratory of Molecular Genetics.
Takahiro OhyamaDepartment of Otolaryngology, University of Southern California, Los Angeles, California 90033.ORCID 0000-0001-6237-7389
Thomas B FriedmanLaboratory of Molecular Genetics.
Michael HoaAuditory Development and Restoration Program, michael.hoa@nih.gov.ORCID 0000-0001-7469-2909
Laboratory of Molecular Genetics · PLOntario Genomics · CANational Institutes of Health · USResearch Institute of Petroleum Exploration and Development · CNMichael & Associates · USUniversity of Michigan · USUniversity of Southern California · US

Funding

Identification of Genes Causing Syndromic And Nonsyndromic Hearing ImpairmentZIADC000039 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI FRIEDMAN, THOMAS · 2009 to 2025
$48.7M
Myosin XVA and Other Genes Essential for Stereocilia MorphogenesisZIADC000048 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI FRIEDMAN, THOMAS · 2009 to 2025
$23.6M
Cellular and Molecular Pathways for Hearing Restoration in the Adult Inner EarZIADC000088 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI HOA, MICHAEL · 2015 to 2025
$14.0M
Mouse Auditory Testing Core FacilityZICDC000080 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI FITZGERALD, TRACY · 2012 to 2025
$8.0M
INTEGRATIVE MECHANISMS OF CORTICAL NEURONSR01DC000086 · NIDCD · YALE UNIVERSITY · PI SHEPHERD, GORDON · 1989 to 2010
$3.6M
Developmental patterning of the cochleaR01DC012085 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OHYAMA, TAKAHIRO · 2013 to 2017
$2.1M
Myosin XVA and Other Genes Essential for Stereocilia MorphogenesisZ01DC000048 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI FRIEDMAN, THOMAS BAER · 1998 to 2008
$1.7M
Molecular and Epigenetic Mechanisms of Hereditary Hearing LossZIADC000089 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$877k
Intramural NIH HHS Z01 DC000048NIDCD NIH HHS R01 DC000086NIDCD NIH HHS R01 DC012085
6 · The paper itself

Abstract

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mice, a deficiency of HGF expression limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness. In humans, noncoding variants in

Indexed as

AnimalsCell CountCochleaEar, InnerEvoked Potentials, Auditory, Brain StemFemaleHair Cells, AuditoryHearing Loss, SensorineuralHepatocyte Growth FactorHomeostasisHumansMaleMiceMice, Inbred C57BLMice, KnockoutNeural CrestHepatocyte Growth FactorHGF protein, mouseRNA ProbesdeafnessDFNB39hepatocyte growth factorHGFneural crest cellsstria vascularis

Identifiers

PMID32152201
PMCPMC7141880
OpenAlexW3010568865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.