ArticleBMJ open respiratory research2020
Complications and discomfort after research bronchoscopy in the MicroCOPD study.
Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Efficacy and safety of supraglottic jet oxygenation and ventilation in Chinese patients undergoing bronchoscopic procedures: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Guidelines on analgosedation, monitoring, and recovery time for flexible bronchoscopy: a systematic review.BMC pulmonary medicine · 2021Pooled it
- Safety of research bronchoscopy with BAL in stable adult patients with cystic fibrosis.PloS one · 2021Trial
- Bilateral tympanic membrane perforation during bronchoscopy in an intensive care unit patient: a case report.BMC pulmonary medicine · 2026Article
- Curative intent therapy of stage I-III non-small cell lung cancer: a patient-centered precision approach to assess, measure, and interpret benefits and harms.Journal of thoracic disease · 2025Article
- Comparative analysis of guidelines and recommendations for sedation during flexible bronchoscopy: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Swedish study participants undergoing research bronchoscopy - a tolerable or unpleasant experience?Frontiers in medicine · 2025Article
- Patient experience with bronchoscopy: topical versus monitored anesthesia.BMC pulmonary medicine · 2024Article
- Spray nozzle for topical anaesthesia during flexible bronchoscopy: a randomised controlled trial.ERJ open research · 2024Article
- A dose escalation study to evaluate the safety of an aerosol BCG infection in previously BCG-vaccinated healthy human UK adults.Frontiers in immunology · 2024Article
- Perceptions about and reasons for participation in research bronchoscopy in Uganda: A qualitative analysis.PloS one · 2023Article
- Effect of different doses of midazolam combined with fentanyl during painless bronchoscopy in adults.American journal of translational research · 2023Article
- Association between oxygen saturation level during bronchoscopy and post-bronchoscopy adverse events: a retrospective cohort study.Respiratory research · 2022Article
- Protein Biomarkers for COPD Outcomes.Chest · 2021Review
- Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.NPJ biofilms and microbiomes · 2021Article
- Oxygen desaturation during flexible bronchoscopy with propofol sedation is associated with sleep apnea: the PROSA-Study.Respiratory research · 2020Observational
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on discomfort and complications from research bronchoscopy in chronic obstructive pulmonary disease (COPD) and asthma is limited. We present complications and discomfort occurring within a week after bronchoscopy, and investigate personal and procedural risk factors.
methods239 subjects with COPD, asthma or without lung disease underwent research bronchoscopies as part of a microbiome study of the lower airways (the MicroCOPD study). Bronchoscopy was done in the supine position with oral scope insertion with the option of light conscious alfentanil sedation. Sampling consisted of protected specimen brushes, bronchoalveolar lavage, small volume lavage and for some, endobronchial biopsies. Bleeding, desaturation, cough, haemodynamic changes, dyspnoea and other events that required an unplanned intervention or early termination of bronchoscopy were prospectively recorded. Follow-up consisted of a telephone interview where subjects rated discomfort and answered questions about fever sensation and respiratory symptoms in the week following bronchoscopy.
resultsAn unplanned intervention or early termination of bronchoscopy was required in 25.9% of bronchoscopies. Three subjects (1.3%) experienced potentially severe complications, of which all recovered without sequelae. COPD subjects experienced more dyspnoea than controls. Sedation and lower age was associated with less unplanned intervention or premature termination. About half of the subjects (47.7%) reported fever. Discomfort was associated with postprocedural fever, dread of bronchoscopy, higher score on the COPD Assessment Test and never-smoking. In subjects undergoing more than one bronchoscopy, the first bronchoscopy was often predictive for complications and postprocedural fever in the repeated bronchoscopy.
conclusionResearch bronchoscopies were not associated with more complications or discomfort in COPD subjects. 47.7% experienced postbronchoscopy fever sensation, which was associated with discomfort.
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