Evidence map›Paper›PMID 32152119›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine.

Anna Z Wec, Denise Haslwanter, Yasmina N Abdiche, Laila Shehata, Nuria Pedreño-Lopez, Crystal L Moyer, Zachary A Bornholdt, Asparouh Lilov, Juergen H Nett, Rohit K Jangra and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

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  12. Review
  13. Flow Cytometry as Immunoassay Tool for Research on Yellow Fever Virus.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  14. Article
  15. Article
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anna Z WecAdimab, LLC, Lebanon, NH 03766.
Denise HaslwanterDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Yasmina N AbdicheCarterra Inc., Salt Lake City, UT 84103.
Laila ShehataAdimab, LLC, Lebanon, NH 03766.
Nuria Pedreño-LopezDepartment of Pathology, University of Miami, Miami, FL 33146.
Crystal L MoyerMapp Biopharmaceutical, Inc., San Diego, CA 92121.
Zachary A BornholdtMapp Biopharmaceutical, Inc., San Diego, CA 92121.
Asparouh LilovAdimab, LLC, Lebanon, NH 03766.
Juergen H NettAdimab, LLC, Lebanon, NH 03766.
Rohit K JangraDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Michael BrownAdimab, LLC, Lebanon, NH 03766.
David I WatkinsDepartment of Pathology, University of Miami, Miami, FL 33146.
Clas AhlmDivision of Infection & Immunology, Department of Clinical Microbiology, Umeå University, 90187 Umeå, Sweden.
Mattias N ForsellDivision of Infection & Immunology, Department of Clinical Microbiology, Umeå University, 90187 Umeå, Sweden.
Félix A ReyStructural Virology Unit, CNRS UMR 3569, Virology Department, Institut Pasteur, 75015 Paris, France.ORCID 0000-0002-9953-7988
Giovanna Barba-SpaethStructural Virology Unit, CNRS UMR 3569, Virology Department, Institut Pasteur, 75015 Paris, France.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-0232-7077
Laura M WalkerAdimab, LLC, Lebanon, NH 03766; laura.walker@adimab.com.

Funding

Host-virus interactions in the control of filovirus entryR01AI134824 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2018 to 2021
$1.9M
NIAID NIH HHS R01 AI134824
6 · The paper itself

Abstract

A comprehensive understanding of the development and evolution of human B cell responses induced by pathogen exposure will facilitate the design of next-generation vaccines. Here, we utilized a high-throughput single B cell cloning technology to longitudinally track the human B cell response to the yellow fever virus 17D (YFV-17D) vaccine. The early memory B cell (MBC) response was mediated by both classical immunoglobulin M (IgM) (IgM

Indexed as

AdultAntibodies, ViralAntigens, ViralB-LymphocytesHumansImmunologic MemoryVaccinationVaccines, AttenuatedViral Envelope ProteinsVirus ReplicationYellow FeverYellow Fever VaccineYellow fever virusAntibodies, ViralAntigens, ViralVaccines, AttenuatedViral Envelope ProteinsYellow Fever Vaccineantibody responsesantiviral vaccinationB cell memorymonoclonal antibodyyellow fever virus

Identifiers

PMID32152119
PMCPMC7104296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.