Evidence map›Paper›PMID 32152097›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Intestinal bile acids directly modulate the structure and function of

John Tam, Simoun Icho, Evelyn Utama, Kathleen E Orrell, Rodolfo F Gómez-Biagi, Casey M Theriot, Heather K Kroh, Stacey A Rutherford, D Borden Lacy, Roman A Melnyk

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
1.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 82 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Gut microbes · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Effects of Bile on PathogenicBiomolecules · 2025
    Article
  11. Lipidomics, Microbiota, and IntestinalInternational journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

John TamMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Simoun IchoMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Evelyn UtamaMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Kathleen E OrrellDepartment of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Rodolfo F Gómez-BiagiMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Casey M TheriotDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.
Heather K KrohDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Stacey A RutherfordDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
D Borden LacyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.ORCID 0000-0003-2273-8121
Roman A MelnykMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; roman.melnyk@sickkids.ca.
University of Toronto · CAVanderbilt University · USHospital for Sick Children · CANorth Carolina State University · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Structural mechanisms of Clostridium difficile pathogenesisR01AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LACY, DANA BORDEN · 2011 to 2020
$3.9M
Structural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2M
Targeted bacterial restoration of colonization resistance against C. difficileR35GM119438 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THERIOT, CASEY MICHELLE · 2016 to 2020
$1.6M
The role of toxins in Clostridium difficile infection pathogenesisI01BX002943 · VA · VETERANS HEALTH ADMINISTRATION · PI LACY, DANA BORDEN · 2016 to 2025
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BLRD VA I01 BX002943NIAID NIH HHS R01 AI095755NIAID NIH HHS R37 AI095755NIDDK NIH HHS P30 DK058404NIGMS NIH HHS R35 GM119438
6 · The paper itself

Abstract

Intestinal bile acids are known to modulate the germination and growth of

Indexed as

Bacterial ToxinsBile Acids and SaltsCaco-2 CellsClostridioides difficileClostridium InfectionsHCT116 CellsHumansIntestinesReceptors, Cell SurfaceBacterial ToxinsBile Acids and SaltsReceptors, Cell Surfacebile acidC. difficilepathogenesisstructuretoxin

Identifiers

PMID32152097
PMCPMC7104382
OpenAlexW3009078156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.