Evidence map›Paper›PMID 32152089›Full record

ArticleDisease models & mechanisms2020

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development.

Kristin M Ates, Tong Wang, Trevor Moreland, Rajalakshmi Veeranan-Karmegam, Manxiu Ma, Chelsi Jeter, Priya Anand, Wolfgang Wenzel, Hyung-Goo Kim, Lynne A Wolfe and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Deficiency in the cell-adhesion moleculeFrontiers in cell and developmental biology · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 3 countries.

Kristin M AtesDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Tong WangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Trevor MorelandJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Rajalakshmi Veeranan-KarmegamDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Manxiu MaDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-1905-3615
Chelsi JeterJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Priya AnandInstitute of Nanotechnology, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany.ORCID 0000-0001-8248-2514
Wolfgang WenzelInstitute of Nanotechnology, Karlsruhe Institute of Technology, 76021 Karlsruhe, Germany.
Hyung-Goo KimNeurological Disorder Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar.
Lynne A WolfeMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7628-5741
Joshi StephenMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4278-6924
David R AdamsMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Thomas MarkelloMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2298-9759
Cynthia J TifftMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3931-1207
Robert SettlageAdvanced Research Computing Unit, Division of Information Technology, Virginia Tech, Blacksburg, VA 24060, USA.
William A GahlMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2494-6752
Graydon B GonsalvezDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-4458-8497
May Christine MalicdanMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-1697-6959
Heather Flanagan-SteetJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.ORCID 0000-0001-8295-0453
Y Albert PanDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA yapan@vtc.vt.edu.ORCID 0000-0001-6485-5487
National Institutes of Health · USAugusta University · USGreenwood Genetic Center · USKarlsruhe Institute of Technology · DEHamad bin Khalifa University · QAVirginia Tech · US

Funding

Human Biochemical GeneticsZIAHG000215 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI GAHL, WILLIAM · 2009 to 2025
$72.6M
PATHOGENIC MECHANISMS OF LYSOSOMAL DISEASER01GM086524 · NIGMS · UNIVERSITY OF GEORGIA · PI STEET, RICHARD · 2009 to 2021
$4.0M
A molecular examination of mRNA localization and cell polarizationR01GM100088 · NIGMS · AUGUSTA UNIVERSITY · PI GONSALVEZ, GRAYDON · 2013 to 2021
$2.7M
Pathogenic Mechanisms of Lysosomal DiseaseR01NS128907 · NINDS · GREENWOOD GENETIC CENTER · PI STEET, RICHARD · 2022 to 2025
$1.2M
USING CELL, FLY, AND ZEBRAFISH MODELS TO UNDERSTAND FAM109A GENE FUNCTION IN UNDIAGNOSED DISEASER21GM119016 · NIGMS · AUGUSTA UNIVERSITY · PI GONSALVEZ, GRAYDON, PAN, YUCHIN ALBERT · 2016 to 2017
$456k
NIGMS NIH HHS R01 GM086524NIGMS NIH HHS R01 GM100088NIGMS NIH HHS R21 GM119016NINDS NIH HHS R01 NS128907
6 · The paper itself

Abstract

A critical barrier in the treatment of endosomal and lysosomal diseases is the lack of understanding of the

Indexed as

EndocytosisAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsCathepsin KCell DifferentiationChondrocytesCiliaCollagen Type IICRISPR-Cas SystemsFaceGenes, DominantHeLa CellsHumansKidneyMorphogenesisAdaptor Proteins, Signal TransducingCathepsin KCollagen Type IIPHETA1 protein, humanPHETA2 protein, humanVesicular Transport ProteinsZebrafish ProteinsEndocytosisIPIP27AOCRLPHETA1Undiagnosed disease

Identifiers

PMID32152089
PMCPMC7272357
OpenAlexW3011723838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.