Evidence map›Paper›PMID 32152076›Full record

ArticleAntimicrobial agents and chemotherapy2020

A Biosynthetic Platform for Antimalarial Drug Discovery.

Mark D Wilkinson, Hung-En Lai, Paul S Freemont, Jake Baum

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Lead/Drug Discovery from Natural Resources.Molecules (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mark D WilkinsonDepartment of Chemistry, Imperial College London, London, United Kingdom.ORCID 0000-0003-1109-3727
Hung-En LaiDepartment of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID 0000-0003-3148-5525
Paul S FreemontDepartment of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom p.freemont@imperial.ac.uk jake.baum@imperial.ac.uk.ORCID 0000-0002-5658-8486
Jake BaumDepartment of Life Sciences, Imperial College London, London, United Kingdom p.freemont@imperial.ac.uk jake.baum@imperial.ac.uk.ORCID 0000-0002-0275-352X
Imperial College London · GBUK Dementia Research Institute · GB

Funding

Medical Research Council MR/N012275/1Wellcome TrustWellcome Trust 100993/Z/13/Z
6 · The paper itself

Abstract

Advances in synthetic biology have enabled the production of a variety of compounds using bacteria as a vehicle for complex compound biosynthesis. Violacein, a naturally occurring indole pigment with antibiotic properties, can be biosynthetically engineered in

Indexed as

Actin CytoskeletonAntimalarialsArtemisininsBiosynthetic PathwaysDrug DiscoveryDrug ResistanceEscherichia coliHigh-Throughput Screening AssaysHumansIndolesMalaria, FalciparumParasitic Sensitivity TestsPlasmodium falciparumSynthetic BiologyAntimalarialsartemisininArtemisininsIndolesviolaceinantimalarialdrug discoverydrug resistancesynthetic biologyviolacein

Identifiers

PMID32152076
PMCPMC7179595
OpenAlexW3009232146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.