Evidence map›Paper›PMID 32152075›Full record

ArticleAntimicrobial agents and chemotherapy2020

Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3.

Vijay Kumar, Christie Tang, Christopher R Bethel, Krisztina M Papp-Wallace, Jacob Wyatt, Eric Desarbre, Robert A Bonomo, Focco van den Akker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Advances in Understanding of the Copper Homeostasis inInternational journal of molecular sciences · 2021
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Vijay KumarDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-2741-8891
Christie TangDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Christopher R BethelLouis Stokes Cleveland Veterans Affairs Medical Center Research Service, Cleveland, Ohio, USA.
Krisztina M Papp-WallaceLouis Stokes Cleveland Veterans Affairs Medical Center Research Service, Cleveland, Ohio, USA.ORCID 0000-0002-9976-7898
Jacob WyattDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Eric DesarbreBasilea Pharmaceutica International Ltd., Basel, Switzerland.
Robert A BonomoDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Focco van den AkkerDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA focco.vandenakker@case.edu.
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USBasilea Pharmaceutica (Switzerland) · CH

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
Targeting Burkholderial β-lactamases: Structure, function, and regulationI01BX002872 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI DONSKEY, CURTIS, PAPP-WALLACE, KRISZTINA MARGARET · 2016 to 2023
–
BLRD VA I01 BX001974BLRD VA I01 BX002872NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI100560NIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant

Indexed as

Anti-Bacterial AgentsBinding SitesCatalytic DomainCephalosporinsCrystallography, X-RayHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular ConformationPenicillin-Binding ProteinsProtein BindingPseudomonas aeruginosaAnti-Bacterial AgentsceftobiproleCephalosporinsPenicillin-Binding Proteinsbeta-lactam antibioticpenicillin-binding proteinprotein crystallography

Identifiers

PMID32152075
PMCPMC7179584
OpenAlexW3010163676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.