Evidence map›Paper›PMID 32152074›Full record

ArticleAntimicrobial agents and chemotherapy2020

Antiviral Activity of a Llama-Derived Single-Domain Antibody against Enterovirus A71.

Peng-Nien Huang, Hsiang-Ching Wang, Hui-Chen Hung, Sung-Nien Tseng, Teng-Yuan Chang, Min-Yuan Chou, Yu-Jen Chen, Yun-Ming Wang, Shin-Ru Shih, John Tsu-An Hsu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Peng-Nien Huang *Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Hsiang-Ching Wang *Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Hui-Chen HungInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Sung-Nien TsengResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Teng-Yuan ChangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Min-Yuan ChouBiomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
Yu-Jen ChenDepartment of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, Taiwan.
Yun-Ming WangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Shin-Ru ShihResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
John Tsu-An HsuDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan tsuanhsu@nhri.edu.tw.
Chang Gung University · TWNational Health Research Institutes · TWNational Yang Ming Chiao Tung University · TWIndustrial Technology Research Institute · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past few decades, enterovirus A71 (EVA71) has caused devastating outbreaks in the Asia-Pacific region, resulting in serious sequelae in infected young children. No preventive or therapeutic interventions are currently available for curing EVA71 infection, highlighting a great unmet medical need for this disease. Here, we showed that one novel single-domain antibody (sdAb), F1, isolated from an immunized llama, could alleviate EVA71 infection both

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCamelids, New WorldCapsid ProteinsCell Line, TumorEnterovirus A, HumanEnterovirus InfectionsEnzyme-Linked Immunosorbent AssayEpitopesMiceMice, TransgenicSingle-Domain AntibodiesAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCapsid ProteinsEpitopesSingle-Domain Antibodiesantiviral researchenterovirus A71hSCARB2 transgenic micesingle-domain antibody

Identifiers

PMID32152074
PMCPMC7179613
OpenAlexW3010295637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.