Evidence map›Paper›PMID 32152049›Full record

ArticleGenetics2020

Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in

Jonna Heldrich, Xiaoji Sun, Luis A Vale-Silva, Tovah E Markowitz, Andreas Hochwagen

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  7. Yeast Tools for Studying Type II Topoisomerases in Budding Yeast.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. Review
  9. Article
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  18. The Role of Topoisomerase II in DNA Repair and Recombination inInternational journal of molecular sciences · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jonna HeldrichDepartment of Biology, New York University, New York 10003.
Xiaoji SunDepartment of Biology, New York University, New York 10003.
Luis A Vale-SilvaDepartment of Biology, New York University, New York 10003.ORCID 0000-0002-9658-5335
Tovah E MarkowitzDepartment of Biology, New York University, New York 10003.
Andreas HochwagenDepartment of Biology, New York University, New York 10003 andi@nyu.edu.ORCID 0000-0002-6184-443X
New York University · USFrederick National Laboratory for Cancer Research · US

Funding

Mechanisms of Chromosome Scale Signal PropagationR01GM111715 · NIGMS · NEW YORK UNIVERSITY · PI HOCHWAGEN, ANDREAS · 2015 to 2022
$2.6M
Chromosomal control of meiotic double-strand break formationR01GM123035 · NIGMS · NEW YORK UNIVERSITY · PI HOCHWAGEN, ANDREAS · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM111715NIGMS NIH HHS R01 GM123035
6 · The paper itself

Abstract

During meiotic prophase, concurrent transcription, recombination, and chromosome synapsis place substantial topological strain on chromosomal DNA, but the role of topoisomerases in this context remains poorly defined. Here, we analyzed the roles of topoisomerases I and II (Top1 and Top2) during meiotic prophase in

Indexed as

DNA Breaks, Double-StrandedChromosomes, FungalDNA Topoisomerases, Type IDNA Topoisomerases, Type IIMeiosisProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA Topoisomerases, Type IDNA Topoisomerases, Type IISaccharomyces cerevisiae ProteinsTOP1 protein, S cerevisiaeTOP2 protein, S cerevisiaeHop1Meiosissynaptonemal complextopo Itopo II

Identifiers

PMID32152049
PMCPMC7198267
OpenAlexW3012211882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.