Evidence map›Paper›PMID 32151973›Full record

ArticleiScience2020

FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism.

Xin Lin, Yae-Huei Liou, Yujun Li, Lu Gong, Yan Li, Yuan Hao, Betty Pham, Shuang Xu, Zhiqiang Jiang, Lijia Li and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

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  9. AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex.American journal of respiratory cell and molecular biology · 2023
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  10. The Influence ofGenes · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Xin LinChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: xlin7@bwh.harvard.edu.
Yae-Huei LiouDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Yujun LiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510180, China.
Lu GongChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yan LiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yuan HaoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Betty PhamChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Shuang XuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zhiqiang JiangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Lijia LiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yifan PengDepartment of Chemical and Biological Engineering, Tufts University, Boston, MA 02155, USA.
Dandi QiaoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Pengda LiuLineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, School of Medicine, The University of North Carolina, Chapel Hill, NC 27514, USA.
Wenyi WeiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Guo ZhangSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Chih-Hao LeeDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Xiaobo ZhouChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: xiaobo.zhou@channing.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · USBoston University · USHuazhong University of Science and Technology · CNTufts University · USUniversity of North Carolina at Chapel Hill · US

Funding

Metabolic Control of Stemness in lung epithelial progenitors by FAM13AR01HL127200 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, ANNY XIAOBO · 2015 to 2024
$4.9M
Identifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5M
Functional Genomic Approaches to Dissect COPD GWAS LociR33HL120794 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K, ZHOU, ANNY XIAOBO · 2016 to 2018
$1.7M
Cellular signaling in muscle metabolic adaptation and energy metabolismR01DK113791 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI LEE, CHIH-HAO · 2017 to 2019
$1.3M
Network-based Methods for Understanding Genetic Determinants and Epistasis in COPDK01HL129039 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI QIAO, DANDI · 2015 to 2019
$844k
Bioenergetic control in immune cell functionR21AI131659 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI LEE, CHIH-HAO · 2018 to 2019
$438k
NHLBI NIH HHS K01 HL129039NHLBI NIH HHS R01 HL127200NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R33 HL120794NIAID NIH HHS R21 AI131659NIDDK NIH HHS R01 DK113791
6 · The paper itself

Abstract

Obesity commonly co-exists with fatty liver disease with increasing health burden worldwide. Family with Sequence Similarity 13, Member A (FAM13A) has been associated with lipid levels and fat mass by genome-wide association studies (GWAS). However, the function of FAM13A in maintaining metabolic homeostasis in vivo remains unclear. Here, we demonstrated that rs2276936 in this locus has allelic-enhancer activity in massively parallel reporter assays (MPRA) and reporter assay. The DNA region containing rs2276936 regulates expression of endogenous FAM13A in HepG2 cells. In vivo, Fam13a

Indexed as

Biological SciencesCell BiologyFunctional Aspects of Cell Biology

Identifiers

PMID32151973
PMCPMC7063182
OpenAlexW3008507508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.