ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2020
Multicenter Study of Metastatic Lung Tumors Targeted by Interventional Cryoablation Evaluation (SOLSTICE).
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- The efficacy and safety of thermal ablation for patients with lung malignancy: a meta-analysis of 12 studies in China.Journal of cardiothoracic surgery · 2022Pooled it
- A Systematic Review and Meta-analysis of Patient Survival and Disease Recurrence Following Percutaneous Ablation of Pulmonary Metastasis.Cardiovascular and interventional radiology · 2022Pooled it
- Pilot Study of Combining Stereotactic Body Radiation Therapy with Pulsed Field Ablation for Oligometastatic/Oligoprogressive Lung Tumors.Journal of vascular and interventional radiology : JVIR · 2025Trial
- Addition of pulsed electric field ablation to SBRT for lung tumors: effect on health-related quality of life.Lung cancer management · 2026Article
- Pulmonary Metastasectomy After Liver Transplantation: Indications, Timing, and Surgical Decision-Making Across Primary Tumor Histologies.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- Robot-assisted CT-guided cryoablation of pulmonary metastases: an IDEAL stage 2a prospective development study.European radiology · 2026Article
- Image-Guided Thermal Ablation of Stage 1 Single and Multiple Primary Lung Carcinoma: Five-Year Outcomes.Medical sciences (Basel, Switzerland) · 2026Article
- Mid-term efficacy and safety of transbronchial cryoablation for stage IA peripheral lung cancer: a retrospective analysis.Translational lung cancer research · 2026Article
- Percutaneous Cryoablation Under Local Anesthesia for Pulmonary Metastases From Colorectal Cancer: Long-Term Outcomes From a Single-Institution Retrospective Cohort.Cancer reports (Hoboken, N.J.) · 2026Article
- CT-Guided Cryoablation Achieves Significantly Higher Local Tumor Control in Sub-Solid Lung Tumors Compared With Solid Tumors: A Retrospective Cohort Study.Thoracic cancer · 2026Article
- The role of bronchoscopic cryoimmunotherapy in non-small cell lung cancer: current evidence and future perspectives.Immunotherapy · 2026Review
- Cryoablation as a Treatment Option for Early-Stage Primary Non-Small Cell Lung Cancer and Lung Metastases: A Narrative Review of Recent Literature.Journal of patient-centered research and reviews · 2026Review
- Association between Three-dimensional Margin Assessment and Local Tumor Control in Percutaneous Lung Cryoablation of Colorectal Metastases.Radiology. Imaging cancer · 2026Article
- Safety and efficacy of microwave ablation versus argon-helium cryoablation for the treatment of primary high-risk pulmonary nodules: a propensity score-matched study.Quantitative imaging in medicine and surgery · 2025Article
- Lung metastases.Nature reviews. Disease primers · 2025Review
- Cryoablation for treatment of peripheral lung metastases from colorectal cancer: a bicenter retrospective study.European radiology · 2025Article
- Safety and Feasibility of Pulsed Electric Field Ablation for Early-Stage Non-Small Cell Lung Cancer Prior to Surgical Resection.Journal of surgical oncology · 2025Article
- Using A Surgical Risk Predictor to Estimate Percutaneous Cryoablation Adverse Event Risk: A Single Center Comparative Analysis.Journal of the American College of Radiology : JACR · 2025Article
- Liquid nitrogen-based cryoablation: complication rates for lung, bone, and soft tissue tumors cryoablation.The British journal of radiology · 2024Article
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Authors and funding
23 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveTo assess the safety and local recurrence-free survival in patients after cryoablation for treatment of pulmonary metastases.
methodsThis multicenter, prospective, single-arm, phase 2 study included 128 patients with 224 lung metastases treated with percutaneous cryoablation, with 12 and 24 months of follow-up. The patients were enrolled on the basis of the outlined key inclusion criteria, which include one to six metastases from extrapulmonary cancers with a maximal diameter of 3.5 cm. Time to progression of the index tumor(s), metastatic disease, and overall survival rates were estimated using the Kaplan-Meier method. Complications were captured for 30 days after the procedure, and changes in performance status and quality of life were also evaluated.
resultsMedian size of metastases was 1.0 plus or minus 0.6 cm (0.2-4.5) with a median number of tumors of 1.0 plus or minus 1.2 cm (one to six). Local recurrence-free response (local tumor efficacy) of the treated tumor was 172 of 202 (85.1%) at 12 months and 139 of 180 (77.2%) at 24 months after the initial treatment. After a second cryoablation treatment for recurrent tumor, secondary local recurrence-free response (local tumor efficacy) was 184 of 202 (91.1%) at 12 months and 152 of 180 (84.4%) at 24 months. Kaplan-Meier estimates of 12- and 24-month overall survival rates were 97.6% (95% confidence interval: 92.6-99.2) and 86.6% (95% confidence interval: 78.7-91.7), respectively. Rate of pneumothorax that required pleural catheter placement was 26% (44/169). There were eight grade 3 complication events in 169 procedures (4.7%) and one (0.6%) grade 4 event.
conclusionPercutaneous cryoablation is a safe and effective treatment for pulmonary metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.