Evidence map›Paper›PMID 32151461›Full record

ReviewBest practice & research. Clinical rheumatology2019

Microbiota-mediated mucosal inflammation in arthritis.

Meagan E Chriswell, Kristine A Kuhn

Open access · greenAbstract readReview
In one paragraph

Review in Best practice & research. Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Meagan E ChriswellDivision of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Ct. Mail Stop B115, Aurora, CO 80045, USA. Electronic address: Meagan.Chriswell@cuanschutz.edu.
Kristine A KuhnDivision of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Ct. Mail Stop B115, Aurora, CO 80045, USA. Electronic address: kristine.kuhn@cuanschutz.edu.
University of Colorado Denver · US

Funding

Research Training in Rheumatology INCLUDE Down Syndrome SupplementT32AR007534 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 1986 to 2026
$6.1M
The role of bacteria-produced indole in the development of autoimmune arthritisR01AR075033 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 2019 to 2026
$3.1M
Development of colonic intraepithelial lymphocytes and their role in epithelial and immune functionK08DK107905 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KUHN, KRISTINE A. · 2016 to 2020
$716k
NIAMS NIH HHS R01 AR075033NIAMS NIH HHS T32 AR007534NIDDK NIH HHS K08 DK107905
6 · The paper itself

Abstract

Mucosal surfaces are a unique symbiotic environment between a host and a vast and diverse ecology of microbes. These microbes have great immunomodulatory potential with respect to the host organism. Indeed, the mucosal immune system strikes a delicate balance between tolerance of commensal organisms and overt inflammation to ward off pathogens. Disruptions of the microbial ecology at mucosal surfaces has been described in a vast number of different human disease processes including many forms of arthritis, and the resulting implications are still being understood to their fullest. Herein, we review the current state of knowledge in microbe-host interactions as it relates to the development of arthritis through bacterial translocation, bacterial metabolite production, education of the immune response, and molecular mimicry.

Indexed as

ArthritisInflammationMicrobiotaHumansImmune ToleranceImmunity, MucosalMicrobiomeMucosal immunityRheumatoid arthritisSpondyloarthritis

Identifiers

PMID32151461
PMCPMC7709780
OpenAlexW3009677901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.