ArticleJournal of biomechanics2020
Incorporation of vasculature in a head injury model lowers local mechanical strains in dynamic impact.
Article in Journal of biomechanics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effect of modeling subject-specific cortical folds on brain injury risk prediction under blunt impact loading.Biomechanics and modeling in mechanobiology · 2026Article
- Anatomical Features and Material Properties of Human Surrogate Head Models Affect Spatial and Temporal Brain Motion under Blunt Impact.Bioengineering (Basel, Switzerland) · 2024Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- Cerebral vascular strains in dynamic head impact using an upgraded model with brain material property heterogeneity.Journal of the mechanical behavior of biomedical materials · 2022Article
- A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location.Frontiers in bioengineering and biotechnology · 2022Article
- Displacement voxelization to resolve mesh-image mismatch: Application in deriving dense white matter fiber strains.Computer methods and programs in biomedicine · 2022Article
- Injury Metrics for Assessing the Risk of Acute Subdural Hematoma in Traumatic Events.International journal of environmental research and public health · 2021Article
- Displacement Error Propagation From Embedded Markers to Brain Strain.Journal of biomechanical engineering · 2021Article
- Article
- Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.Scientific reports · 2021Article
- Instantaneous Whole-Brain Strain Estimation in Dynamic Head Impact.Journal of neurotrauma · 2021Article
- The importance of modeling the human cerebral vasculature in blunt trauma.Biomedical engineering online · 2021Article
- Cerebral Vasculature Influences Blast-Induced Biomechanical Responses of Human Brain Tissue.Frontiers in bioengineering and biotechnology · 2021Article
- A Machine Learning Approach to Investigate the Uncertainty of Tissue-Level Injury Metrics for Cerebral Contusion.Frontiers in bioengineering and biotechnology · 2021Article
- Validation and Comparison of Instrumented Mouthguards for Measuring Head Kinematics and Assessing Brain Deformation in Football Impacts.Annals of biomedical engineering · 2020Article
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2 authors.
Funding
Abstract
Cerebral vasculature is several orders of magnitude stiffer than the brain tissue. However, only a handful of studies have investigated its potential stiffening effect on dynamic brain strains; yet, they report contradictory findings. Here, we reanalyze the cerebrovascular stiffening effect by incorporating vasculature derived from the latest neuroimaging atlases into a re-meshed Worcester Head Injury Model using an embedded element method. Regional brain strains with and without vasculature were simulated using a reconstructed, predominantly sagittal head impact. Using the two previously adopted linear or non-linear vessel material models, we reproduced the earlier conflicting results (~40% vs. ~1-6% in regional strain reductions). Nevertheless, with refitted non-linear material models chosen to represent the average dynamic tension behaviors of arteries and veins, respectively, inclusion of vasculature reduced regional brain strains by ~13-36% relative to the baselines without vasculature. Compared to the whole brain baseline response, inclusion of vasculature led to an element-wise linear regression slope of 0.8 and a Pearson correlation coefficient of 0.8. The vascular stiffening effect appears mild for the whole brain but more significant locally, which should not be ignored in head injury models. Nevertheless, more work is necessary to investigate the cerebrovascular mechanical behaviors and loading environment to allow for more biofidelic modeling of the brain in the future.
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