ArticleLancet (London, England)2020
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.
Article in Lancet (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 1,693 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective International Lung UltraSound Analysis (ILUSA) Study in Tertiary Maternity Wards During the SARS-CoV-2 Pandemic
Randomized Trial Evaluating Effect of Outpatient Hydroxychloroquine on Reducing Hospital Admissions in Pregnant Women With SARS-CoV-2 Infection: HyPreC Trial
COVID-19 and Obstetric Transmission
Genetic Risk Factors Predictive of the Occurrence of Maternally Diagnosed Perinatal Depression in Women
Who cites it
1,693 citing papers in PubMed, 3 syntheses or guidelines pooled it, 4,017 citations in OpenAlex.
- The prevalence of mental ill-health in women during pregnancy and after childbirth during the Covid-19 pandemic: a systematic review and Meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Pooled it
- Pooled it
- The link between nutrient intake and anthropometric indices with COVID-19 infection in pregnant women.BMC pregnancy and childbirth · 2026Article
- AI-Assisted segmentation and volumetric reconstruction of radiographs through multi-angular scintillation imaging.Nature communications · 2026Article
- SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues.Nature communications · 2026Article
- Leveraging knowledge graphs and large language models for integrating molecular variants and clinical insights in COVID-19 research.Biosafety and health · 2026Article
- Maternal and neonatal outcomes following SARS-CoV-2 infection in an unvaccinated pregnant cohort: A trimester-specific analysis.PloS one · 2026Article
- Impact of SARS-CoV-2 Omicron infection on late pregnancy: an analysis of clinical characteristics, pathology of placenta and outcomes in a case-control study.Open medicine (Warsaw, Poland) · 2026Article
- Endogenous Biomarkers Analysis and False-Negative Results for SARSCov2 Using two Commercial RT-PCR Diagnostic Kits.Iranian journal of pathology · 2026Article
- Laboratory changes and clinical correlates of disease severity in hospitalized pregnant women with COVID-19.Annals of medicine and surgery (2012) · 2025Article
- Neonatal pulmonary function tests in infants born to COVID-19 positive mothers.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Fear of COVID-19, Stress, Fear of Childbirth, Hardiness and Life Satisfaction in Polish Pregnant Women During the Pandemic.Journal of clinical medicine · 2025Article
- The Experience of Breastfeeding Women During the Pandemic in Romania.Children (Basel, Switzerland) · 2025Article
- The prevalence of symptomatic COVID-19 infection among pregnant women and its relationship with pregnancy outcomes: a retrospective review of the medical records in North East Iran.BMC pregnancy and childbirth · 2025Article
- The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway.Journal of neuroinflammation · 2025Review
- Trend of psychological symptoms from pregnancy to postpartum: a prospective study during COVID-19 pandemic.Discover mental health · 2025Article
- Admission and outcomes of COVID-19 among chronic obstructive pulmonary diseases patients in Africa: protocol for a systematic review and meta-analysis.International health · 2025Article
- Coronavirus disease 2019-associated liver injury in pregnancy: A case report.The Journal of international medical research · 2025Article
- Double balloon catheter induction of labor in pregnant women with COVID-19 infection.BMC pregnancy and childbirth · 2025Article
1,633 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection.
methodsClinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation.
findingsAll nine patients had a caesarean section in their third trimester. Seven patients presented with a fever. Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. Fetal distress was monitored in two cases. Five of nine patients had lymphopenia (<1·0 × 10⁹ cells per L). Three patients had increased aminotransferase concentrations. None of the patients developed severe COVID-19 pneumonia or died, as of Feb 4, 2020. Nine livebirths were recorded. No neonatal asphyxia was observed in newborn babies. All nine livebirths had a 1-min Apgar score of 8-9 and a 5-min Apgar score of 9-10. Amniotic fluid, cord blood, neonatal throat swab, and breastmilk samples from six patients were tested for SARS-CoV-2, and all samples tested negative for the virus.
interpretationThe clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy.
fundingHubei Science and Technology Plan, Wuhan University Medical Development Plan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.