ArticlePsychological medicine2021
Autistic traits in psychotic disorders: prevalence, familial risk, and impact on social functioning.
Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The association between autism and psychosis and the tools used to measure it: An updated systematic review and meta-analysis.The British journal of clinical psychology · 2026Pooled it
- Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis.Journal of autism and developmental disorders · 2022Pooled it
- Assessment and correlates of autistic symptoms in Schizophrenia Spectrum Disorders measured with the PANSS Autism Severity Score: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Examining the association between autistic traits and psychopathology in the general population: are there sex differences?European archives of psychiatry and clinical neuroscience · 2026Article
- Psychometric properties of the PANSS autism severity score (PAUSS) in young peoples at clinical high risk for psychosis: does it really measure autistic features?European archives of psychiatry and clinical neuroscience · 2026Article
- Evaluating the Prodromal Questionnaire-16 for Screening and Prediction of Psychosis in Autistic Adults: Cross-Sectional and Longitudinal Findings From a National Cohort.Schizophrenia bulletin · 2026Article
- Arginine-vasopressin systems in autistic phenotype schizophrenia: effect of a genetic variant of AVPR1a and AVPR1b.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Paternal Broader Autism Phenotype and Adolescent Avoidant Attachment as Independent Predictors of Negative Symptoms in Early Psychosis.Brain and behavior · 2026Article
- Autistic Trait Profiles Across Mood and Psychotic Spectrum Disorders: A Transdiagnostic Outpatient Study.Journal of clinical medicine · 2026Article
- Autistic symptomatology within the schizophrenia spectrum disorders: A narrative review of cognitive and social correlates and treatment implications.Schizophrenia research. Cognition · 2026Review
- Psychotic Spectrum Symptoms in Adults with Autism Spectrum Disorder and in Their First-Degree Relatives.Brain sciences · 2026Article
- Cognitive Profiles in Adolescents and Young Adults With Co-Occurring Autism and First-Episode Psychosis: A Preliminary Neuropsychological Investigation.PsyCh journal · 2026Article
- What Does the PANSS Autism Severity Score (PAUSS) Really Measure in Patients With First Episode Psychosis? Critical Considerations.Journal of autism and developmental disorders · 2026Article
- What autism features in first episode psychosis? Results from a 2-year follow-up study.European archives of psychiatry and clinical neuroscience · 2025Article
- Autistic traits, psychosis proneness, and empathy in preadolescents: A network analysis.Scientific reports · 2025Article
- Clinical implications of autistic features in the psychosis spectrum: a cross-sectional study using path analysis.BMC psychiatry · 2025Article
- Response Inhibition in Autistic Children Predicts Positive Psychotic Symptoms in Young Adulthood-Results from an 8-Year Follow-up Study.Journal of autism and developmental disorders · 2025Article
- Autistic Traits in Schizophrenia: Immune Mechanisms and Inflammatory Biomarkers.International journal of molecular sciences · 2025Review
- Autistic Traits Are Associated with Suicidal Thoughts and Behaviors Among Patients with Borderline Personality Disorder.Brain sciences · 2025Article
- Validation of the Hebrew version of the Community Assessment of Psychic Experiences in a sample of Israeli Hebrew speakers.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevalence estimates of autistic traits in individuals with psychotic disorders (PD) vary greatly and it is unclear whether individuals with a familial risk (FR) for psychosis have an increased propensity to display autistic traits. Furthermore, it is unknown whether the presence of comorbid autism traits disproportionally affects the cognitive and behavioral aspects of social functioning in PD.
methodsIn total, 504 individuals with PD, 587 unaffected siblings with FR, and 337 typical comparison (TC) individuals (16-50 years) were included. Autistic and psychotic traits were measured with the Autism Spectrum Quotient (AQ) and the Community Assessment of Psychic Experiences (CAPE). Social cognition was assessed with the Picture Sequencing Task (PST) and social behavior with the Social Functioning Scale (SFS).
resultsFor PD 6.5% scored above AQ clinical cut-off (⩾32), 1.0% for FR, and 1.2% for TC. After accounting for age, sex, and IQ, the PD group showed significantly more autistic traits and alterations in social behavior and cognition, while FR and TC only displayed marginal differences. Within the PD group autistic traits were a robust predictor of social behavior and there were no interactions with positive psychotic symptoms.
conclusionsLevels of autistic traits are substantially elevated in PD and have a profoundly negative association with social functioning. In contrast, autistic traits above the clinical cut-off are not elevated in those with FR, and only marginally on a dimensional level. These findings warrant specific clinical guidelines for psychotic patients who present themselves with autistic comorbidity to help address their social needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.