ArticleBMC medical genomics2020
Transcriptome analysis of HPV-induced warts and healthy skin in humans.
Article in BMC medical genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Molecular insights and therapeutic innovations in low-risk human papillomavirus-associated cutaneous wart.Molecular biology reports · 2026Review
- In silico drug repurposing for potential HPV-induced skin wart treatment - A comparative transcriptome analysis.Journal, genetic engineering & biotechnology · 2025Article
- Role of the human cytochrome b561 family in iron metabolism and tumors (Review).Oncology letters · 2025Review
- Article
- Gene Expression Dysregulation in Whole Blood of Patients withInternational journal of molecular sciences · 2024Article
- Development of human papillomavirus and its detection methods (Review).Experimental and therapeutic medicine · 2024Review
- Article
- Decoding the immune landscape: a comprehensive analysis of immune-associated biomarkers in cervical carcinoma and their implications for immunotherapy strategies.Frontiers in genetics · 2024Article
- Review
- Article
- Immunothrombotic Mechanisms Induced by Ingenol Mebutate Lead to Rapid Necrosis and Clearance of Anogenital Warts.International journal of molecular sciences · 2022Article
- Article
- A unique Levey-Jennings control chart used for internal quality control in human papillomavirus detection.Virology journal · 2022Article
- Consideration of underlying immunodeficiency in refractory or recalcitrant warts: A review of the literature.Skin health and disease · 2022Review
- Development of Verruca Plana from Human Papillomavirus 78 Dependent on Host Immune State.Acta dermato-venereologica · 2021Article
- Article
- HPV infection upregulates the expression of ZNT-1 in condyloma acuminatum.European journal of histochemistry : EJH · 2021Article
- Global gene methylation profiling of common warts caused by human papillomaviruses infection.Saudi journal of biological sciences · 2021Article
- Genome-Wide CpG Island Methylation Profiles of Cutaneous Skin with and without HPV Infection.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human papillomaviruses (HPV) are a group of viruses that, depending on the strain, can cause cancer or the formation of benign growths known as warts. Scarce information exists with regard to the genetic nature of non-genital cutaneous warts induced by the human papillomavirus (HPV).
methodsThe main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. After obtaining shave biopsies of common warts and healthy skin from twelve Arab males, we were able to analyze the transcriptomes of 24 paired cases and controls.
resultsCommon warts were found to possess a highly significant and unique molecular signature. Many of the most up-regulated (KRT16, EPGN, and ABCG4) and down-regulated genes (C15orf59, CYB561A3, and FCGRT) in warts were the subject of little investigation in the published literature. Moreover, the top 500 differentially expressed genes were found to be associated with immune and autoimmune pathways, such as the neutrophil degranulation, toll-like receptor 7/8 (TLR 7/8) cascade, toll-like receptor 9 (TLR9) cascade, and toll-like receptor 10 (TLR10) pathways, among others.
conclusionsOur findings are particularly important because they serve as the most comprehensive to date with regard to the modulation of human skin gene expression by HPV infection.
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