ArticleReproductive biology and endocrinology : RB&E2020
Secular trends in testosterone- findings from a large state-mandate care provider.
Article in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Temporal trends in serum testosterone and luteinizing hormone levels indicate an ongoing resetting of hypothalamic-pituitary-gonadal function in healthy men: a systematic review.Journal of endocrinological investigation · 2025Pooled it
- Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.Ageing research reviews · 2022Pooled it
- Article
- Elevated Estradiol and DHT Levels in the Prostatic Stroma as Key Drivers of Benign Prostatic Hyperplasia Pathogenesis.International journal of molecular sciences · 2026Article
- The Global Decline in Sperm Count and Testosterone Levels: Trends, Mechanisms, and Environmental Drivers.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- Sex differences in macro- and microvascular reactivity - a systematic review and meta-analysis.American journal of preventive cardiology · 2025Review
- Testosterone replacement therapy and spermatogenesis in reproductive age men.Nature reviews. Urology · 2025Review
- Trends in Indicators of Violence Among Adolescents in Europe and North America 1994-2022.International journal of public health · 2025Article
- Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review.Journal of personalized medicine · 2024Review
- What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms.Frontiers in reproductive health · 2024Review
- Dietary trends and the decline in male reproductive health.Hormones (Athens, Greece) · 2023Review
- Effects of cigarette smoking on semen quality, reproductive hormone levels, metabolic profile, zinc and sperm DNA fragmentation in men: results from a population-based study.Frontiers in endocrinology · 2023Article
- Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance.Clinical epigenetics · 2022Article
- Testosterone deficiency and the aging male.International journal of impotence research · 2022Review
- The changing tide of human fertility.Human reproduction (Oxford, England) · 2022Article
- Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- Global warming and testis function: A challenging crosstalk in an equally challenging environmental scenario.Frontiers in cell and developmental biology · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies from the US and Europe have shown a population-level decline in serum testosterone in men from 1970's to early 2000's. However, to the best of our knowledge, no study examining population-level decline in testosterone has been published in more recent years. The study objective was therefore to examine secular trends in testosterone levels among Israeli men in the first and second decades of the twenty-first century,
methodsAll incident total testosterone performed between1/2006 and 3/2019 among 102,334 male members of a large health organization.
resultsA significant (p < 0.001) and prominent trend of age-independent decline in the testosterone levels was recorded during the study period for most age groups.
conclusionsThere was a highly significant age-independent decline in total testosterone in the first and second decades of the twenty-first century. The decline was unlikely to be explained by increasing rates of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.