Evidence map›Paper›PMID 32151032›Full record

ArticleJournal of clinical medicine2020

Influence of Preformed Antibodies in Liver Transplantation.

Isabel Legaz, Francisco Boix, Manuela López, Rafael Alfaro, José A Galián, Santiago Llorente, Jose A Campillo, Carmen Botella, Pablo Ramírez, Francisco Sánchez-Bueno and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. The Jewish Perspectives on Xenotransplantation.Rambam Maimonides medical journal · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Identification of peripheral CD154Clinical and experimental immunology · 2021
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Isabel LegazDepartment of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence "Campus Mare Nostrum", Faculty of Medicine, University of Murcia, 30100 Murcia, Spain.ORCID 0000-0002-1140-4313
Francisco BoixImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.ORCID 0000-0002-3926-7920
Manuela LópezImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Rafael AlfaroImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
José A GaliánImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Santiago LlorenteImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Jose A CampilloImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Carmen BotellaImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Pablo RamírezSurgery Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Francisco Sánchez-BuenoSurgery Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
José A PonsDigestive Medicine Service. Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
María R Moya-QuilesImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Alfredo MinguelaImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.ORCID 0000-0003-2472-5893
Manuel MuroImmunology Service, Murcia Institute of Biosanitary Research (IMIB) and Biomedical Research Center in Liver and Digestive Diseases Network (CIBERehd), Virgen de la Arrixaca University Clinical Hospital (HCUVA), 30120 Murcia, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESUniversidad de Murcia · ES

Funding

European Fund of Regional Development (FEDER) with the principle of "A manner to build Europe". PI19/01194Instituto de Salud Carlos III (ISCIII) PI11/02686Spanish Ministry of Economy and Competitiveness PI15/01370
6 · The paper itself

Abstract

The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (-CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to -CDC-CM patients (23.1% vs. 59.1%,

Indexed as

alcoholic cirrhosiscauses of deathcrossmatchdonor-specific antibodiesforensic medicineliver rejectionmedico-legal autopsysurvival

Identifiers

PMID32151032
PMCPMC7141359
OpenAlexW3009615357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.