Evidence map›Paper›PMID 32150865›Full record

ArticleMolecules (Basel, Switzerland)2020

Design, Synthesis, and Biological Evaluation of Aromatic Amide-Substituted Benzimidazole-Derived Chalcones. The Effect of Upregulating

Lintao Wu, Yuting Yang, Zhijun Wang, Xi Wu, Feng Su, Mengyao Li, Xiaobi Jing, Chun Han

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lintao WuDepartment of Chemistry, Changzhi University, Changzhi, Shanxi 046011, China.ORCID 0000-0002-8768-9036
Yuting YangUniversity of Michigan Medical School, Ann Arbor, MI 48109, USA.
Zhijun WangDepartment of Chemistry, Changzhi University, Changzhi, Shanxi 046011, China.
Xi WuDepartment of Chemistry, Changzhi University, Changzhi, Shanxi 046011, China.ORCID 0000-0002-0667-8117
Feng SuDepartment of Chemistry, Changzhi University, Changzhi, Shanxi 046011, China.ORCID 0000-0003-3608-1431
Mengyao LiDepartment of Chemistry, Changzhi University, Changzhi, Shanxi 046011, China.ORCID 0000-0002-6044-8355
Xiaobi JingSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China.ORCID 0000-0001-7523-2314
Chun HanDepartment of Chemistry, Changzhi University, Changzhi, Shanxi 046011, China.ORCID 0000-0002-5913-5001
Changzhi University · CNUniversity of Michigan · USYangzhou University · CN

Funding

National Natural Science Foundation of China 21402012National Natural Science Foundation of China 21907010Natural Science Foundation of Shanxi Province 201801D221082Natural Science Foundation of Shanxi Province 201901D211465Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi 2019L0913
6 · The paper itself

Abstract

A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized. All of the chalcone compounds were tested for their in vitro antitumor activity against human cancer cell lines (HCT116, HepG2, A549, and CRL-5908). The antiproliferative activity of compounds

Indexed as

Chemistry Techniques, SyntheticDrug DesignAmidesAntineoplastic AgentsBenzimidazolesCell CycleCell Line, TumorCell ProliferationChalconesDose-Response Relationship, DrugGene Expression Regulation, NeoplasticHumansMolecular StructureStructure-Activity RelationshipTumor Suppressor Protein p53AmidesAntineoplastic AgentsBenzimidazolesChalconesTumor Suppressor Protein p53antiproliferative activitiesaromatic amide-substitutedchalconesTP53 proteinupregulating

Identifiers

PMID32150865
PMCPMC7179225
OpenAlexW3009351687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.