Evidence map›Paper›PMID 32150801›Full record

ArticleVaccines2020

Influenza Vaccination in Italian Healthcare Workers (2018-2019 Season): Strengths and Weaknesses. Results of a Cohort Study in Two Large Italian Hospitals.

Donatella Panatto, Piero Luigi Lai, Stefano Mosca, Elvina Lecini, Andrea Orsi, Alessio Signori, Silvana Castaldi, Elena Pariani, Laura Pellegrinelli, Cristina Galli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Vaccination Open Day: A Cross-Sectional Study on the 2023 Experience in Lombardy Region, Italy.International journal of environmental research and public health · 2024
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  16. Is Immuno-modulation the Key to COVID-19 Pandemic?Indian journal of orthopaedics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Donatella PanattoDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.ORCID 0000-0002-2677-0551
Piero Luigi LaiDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.ORCID 0000-0003-3063-4154
Stefano MoscaInteruniversity Research Center on Influenza and Other Transmissible Infections (CIRI-IT), Via Pastore 1, 16132 Genoa, Italy.
Elvina LeciniDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.
Andrea OrsiDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.ORCID 0000-0002-2433-9610
Alessio SignoriDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.
Silvana CastaldiDepartment of Biomedical Sciences for Health, University of Milan, Via C. Pascal 36, 20133 Milano, Italy.ORCID 0000-0003-1716-6624
Elena ParianiInteruniversity Research Center on Influenza and Other Transmissible Infections (CIRI-IT), Via Pastore 1, 16132 Genoa, Italy.
Laura PellegrinelliDepartment of Biomedical Sciences for Health, University of Milan, Via C. Pascal 36, 20133 Milano, Italy.ORCID 0000-0003-2344-6032
Cristina GalliDepartment of Biomedical Sciences for Health, University of Milan, Via C. Pascal 36, 20133 Milano, Italy.ORCID 0000-0002-0450-4156
Giovanni AnselmiDepartment of Biomedical Sciences for Health, University of Milan, Via C. Pascal 36, 20133 Milano, Italy.
Giancarlo IcardiDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.ORCID 0000-0002-8463-8487
Ciri-It TeamDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, Italy.
University of Genoa · ITUniversity of Milan · IT

Funding

DRIVE project - Innovative Medicines Initiative 2 Joint 777363
6 · The paper itself

Abstract

backgroundAnnual vaccination is the most effective way to combat influenza. As influenza viruses evolve, seasonal vaccines are updated annually. Within the European project Development of Robust and Innovative Vaccine Effectiveness (DRIVE), a cohort study involving Italian healthcare workers (HCWs) was carried out during the 2018-2019 season. Two aims were defined: to measure influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza cases and to conduct an awareness-raising campaign to increase vaccination coverage.

methodsEach subject enrolled was followed up from enrollment to the end of the study. Each HCW who developed ILI was swabbed for laboratory confirmation of influenza. Influenza viruses were identified by molecular assays. A Cox regression analysis, crude and adjusted for confounding variables, was performed to estimate the IVE.

resultsAmong the 4483 HCWs enrolled, vaccination coverage was 32.5%, and 308 ILI cases were collected: 23.4% were positive for influenza (54.2% A(H1N1) pdm09; 45.8% A(H3N2)). No influenza B viruses were detected. No overall IVE was observed. Analyzing the subtypes of influenza A viruses, the IVE was estimated as 45% (95% CI: -59 to 81) for A(H1N1) pdm09.

conclusionsVaccination coverage among HCWs increased. Study difficulties and the circulation of drifted variants of A(H3N2) could partly explain the observed IVE.

Indexed as

healthcare workersinfluenzainfluenza vaccinationinfluenza vaccination coveragelaboratory-confirmed influenza

Identifiers

PMID32150801
PMCPMC7157508
OpenAlexW3010641180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.