ArticleAmerican journal of respiratory cell and molecular biology2020
Role of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells.
Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Shared Transcriptomic Signatures and Network Interactions Between Lung Adenocarcinoma and Asthma.International journal of molecular sciences · 2026Article
- A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease.Biomolecules · 2026Review
- Regulation of Mitochondrial Metabolism byCells · 2025Article
- Ten-Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy.MedComm · 2025Review
- Regulation of DNA methylation in lesional tissue of children with atopic dermatitis.Frontiers in medicine · 2025Article
- SilencingEnvironmental epigenetics · 2025Article
- Investigating the Underlying Mechanisms of Ma-Xing-Shi-Gan-Tang on Asthma via Metabolomics and Network Pharmacology.Journal of inflammation research · 2025Article
- Epigenetics-targeted drugs: current paradigms and future challenges.Signal transduction and targeted therapy · 2024Review
- TET1 Regulates Nestin Expression and Human Airway Smooth Muscle Proliferation.American journal of respiratory cell and molecular biology · 2024Article
- Identification of genetic variants associated with clinical features of sickle cell disease.Scientific reports · 2024Article
- Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers.Genome medicine · 2023Article
- Research advances in airway remodeling in asthma: a narrative review.Annals of translational medicine · 2022Review
- Metabolomic profiling of samples from pediatric patients with asthma unveils deficient nutrients in African Americans.iScience · 2022Article
- Airway Wall Remodeling in Childhood Asthma-A Personalized Perspective from Cell Type-Specific Biology.Journal of personalized medicine · 2021Review
- Update in Adult Asthma 2020.American journal of respiratory and critical care medicine · 2021Review
- Multigenerational Epigenetic Regulation of Allergic Diseases: Utilizing an Experimental Dust Mite-Induced Asthma Model.Frontiers in genetics · 2021Article
- Multiplex-Heterogeneous Network-Based Capturing Potential SNP "Switches" of Pathways Associating With Diverse Disease Characteristics of Asthma.Frontiers in cell and developmental biology · 2021Article
- Isocitrate dehydrogenase variants in cancer - Cellular consequences and therapeutic opportunities.Current opinion in chemical biology · 2020Review
- A Fresh Take on the "TCA" Cycle: TETs, Citrate, and Asthma.American journal of respiratory cell and molecular biology · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Global DNA hydroxymethylation mediated by the TET (ten-eleven translocation) enzyme was induced in allergen-induced airway hyperresponsiveness in mouse lung tissues and specifically in isolated airway smooth muscle (ASM) cells. TET is an α-ketoglutarate (α-KG)-dependent enzyme, and the production of α-KG is catalyzed by IDH (isocitrate dehydrogenase). However, the role of IDH in the regulation of DNA hydroxymethylation in ASM cells is unknown. In comparison with nonasthmatic cells, asthmatic ASM cells exhibited higher TET activity and
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Registered trials
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