Trial reportPloS one2020
Safety, prosthesis wearing time and health-related quality of life of lower extremity bone-anchored prostheses using a press-fit titanium osseointegration implant: A prospective one-year follow-up cohort study.
Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Meta-analytic evaluation of complications and longevity of bone-anchored prostheses in lower extremity amputees: does design matter?Musculoskeletal surgery · 2026Pooled it
- Comparison of Quality of Life in Transfemoral Amputee Using Bone-Anchored Prostheses vs. Socket Prostheses: A Systemic Review and Meta-Analysis.Orthopaedic surgery · 2025Pooled it
- Bone-anchored prostheses for transfemoral amputation: a systematic review of outcomes, complications, patient experiences, and cost-effectiveness.Frontiers in rehabilitation sciences · 2024Pooled it
- Tibial Bone-Anchored Prostheses: A Narrative Review of the Literature and Reflection on 10 Years of Surgical Practice.Annals of biomedical engineering · 2026Review
- A Preclinical Approach to 3D-Printed Osseointegration Prosthesis: Improving Functional Outcomes and Reducing Complications in Residual Limb Reconstruction.Annals of biomedical engineering · 2026Article
- Femoral fracture risk in transfemoral amputees with bone-anchored prosthetic limbs during activities of daily living.Journal of orthopaedic surgery and research · 2025Article
- Wearing Time, Quality of Life, and Complications of Lower Limb Bone-anchored Prostheses: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2025Article
- How To Improve Patient Selection in Individuals With Lower Extremity Amputation Using a Bone-anchored Prosthesis.Clinical orthopaedics and related research · 2025Article
- Altered cumulative joint moments and increased joint moment symmetry during sit-to-stand transitions for transfemoral bone-anchored limb users: A case series.Clinical biomechanics (Bristol, Avon) · 2025Article
- Surgical technique of a transcutaneous osseointegration prosthesis system (TOPS) for transtibial amputees.Operative Orthopadie und Traumatologie · 2025Review
- Surgical technique of minor revision of a transcutaneous osseointegration prosthetic system (TOPS) with implant retention.Operative Orthopadie und Traumatologie · 2025Review
- Lower Extremity Osseointegration Postoperative Rehabilitation Protocols: A Scoping Review.Physical therapy · 2025Article
- A one-year follow-up case series on gait analysis and patient-reported outcomes for persons with unilateral and bilateral transfemoral amputations undergoing direct skeletal fixation.Journal of neuroengineering and rehabilitation · 2024Article
- Advantages of customization of osseointegrated implants in transfemoral amputees: a comparative analysis of surgical planning.Journal of orthopaedic surgery and research · 2024Article
- Radiological evaluation before and after treatment with an osseointegrated bone-anchor following major limb amputation-a guide for radiologists.Skeletal radiology · 2024Review
- Complications Following Osseointegrated Transfemoral and Transtibial Implants: A Systematic Review.Cureus · 2024Review
- Bone-anchored prostheses for lower limb amputation in a French cohort with 1-15 years of follow-up: implant survival rates, mechanical complications, and reported outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Utility of Thermal Imaging in Predicting Superficial Infections in Transfemoral Osseointegrated Implants.Plastic and reconstructive surgery. Global open · 2024Article
- Article
- Osseointegrated prostheses for the rehabilitation of patients with transfemoral amputations: A prospective ten-year cohort study of patient-reported outcomes and complications.Journal of orthopaedic translation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe described safety and functional one-year follow-up outcomes of individuals with lower limb amputation treated with bone-anchored prostheses using titanium press-fit osseointegration implants.
methodsAll consecutive individuals treated between March 2015 and June 2018 with curved osseointegration femur implant (OFI-C) indicated for a long femoral remnant, gamma osseointegration femur implant (OFI-Y) indicated for a short femoral remnant, or osseointegration tibia implant (OTI) were eligible for this study. All adverse events were evaluated, infections were graded as follows: grade 1 and 2: low- and high-grade soft tissue infection, respectively, grade 3: deep bone infection, grade 4: septic implant failure. Functional outcome measures included prosthesis wearing time (PUS), health-related quality of life (GS), and the overall situation as an amputee (GS Q3); evaluated with the Questionnaire of persons with trans-femoral amputation (Q-TFA) before surgery and at one-year follow-up.
resultsNinety of 91 individuals were included (mean age: 54±14 yrs, 26 females); treated with 53, 16 and 21 OFI-C, OFI-Y and OTI, respectively. Soft tissue infections (grade 1: 11 events, grade 2: 10 events) were treated successfully with antibiotics except in two (OFI-C and OFI-Y), who required additional surgery due to recurrent stoma irritation and peri-stoma abscess drainage. One individual with dysvascular amputation (OTI) developed septic implant loosening and occlusion of the femoral artery resulting in a transfemoral amputation. No aseptic loosening's occurred. One individual (OFI-Y) required stoma surgical refashioning due to soft tissue redundancy. At baseline mean ±SD and median (25th to 75th PCTL) Q-TFA PUS and GS were 52±39, 52(7-90) and 40±19, 42(25-50) and improved significantly to 88±18, 90 (90-100) and 71±15, 75 (67-83) at one-year follow-up. The GS Q3 improved over time.
conclusionTitanium osseointegration implants can be safely used within a one-year follow-up period. The performance improved compared to the use of a socket-suspended prosthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.