ArticlePloS one2020
Effect of Xpert MTB/RIF testing introduction and favorable outcome predictors for tuberculosis treatment among HIV infected adults in rural southern Mozambique. A retrospective cohort study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
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- Clinical mentorship and TB detection in prison health facilities.IJTLD open · 2026Article
- Factors associated with unsuccessful tuberculosis treatment outcome in children in four provinces of Mozambique: a retrospective cohort study, 2018-2021.BMC infectious diseases · 2026Article
- Baseline characteristics associated with mortality among children living with HIV initiating ART at a rural district HIV clinic of Mozambique.Scientific reports · 2026Article
- Incidence and predictors of mortality among persons with rifampicin-resistant tuberculosis and HIV in Mozambique.Scientific reports · 2025Article
- The treatment success rate and associated factors among pulmonary bacteriologically confirmed and pulmonary clinically diagnosed drug susceptible TB coinfected with HIV in Teso Sub-Region, North-Eastern Uganda 2020-2021. a retrospective study.BMC infectious diseases · 2025Article
- Predictors of Tuberculous Meningitis Mortality Among Persons with HIV in Mozambique.Tropical medicine and infectious disease · 2025Article
- Article
- Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique.Scientific reports · 2022Article
- Predictors of attrition among adults in a rural HIV clinic in southern Mozambique: 18-year retrospective study.Scientific reports · 2021Article
- Lipoarabinomannan Antigen Assay (TB-LAM) for Diagnosing Pulmonary Tuberculosis in Children with Severe Acute Malnutrition in Mozambique.Journal of tropical pediatrics · 2021Article
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7 authors.
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Abstract
backgroundGlobal roll out of Xpert MTB/RIF technology has resulted in dramatic changes in TB diagnosis. However, benefits in resource-limited, high-burden TB/HIV settings, remain to be verified. In this paper we describe the characteristics of a large cohort of TB patients in a rural hospital in Southern Mozambique before and after Xpert MTB/RIF introduction, together with some determinants of favorable treatment outcome.
methodsWe conducted a retrospective cohort study of TB infected patients ≥15 years of age, diagnosed and treated at Carmelo Hospital of Chókwè between January 1, 2006 and December 31, 2017. Patient demographic and clinical characteristics, and treatment outcomes were recorded and compared before and after Xpert MTB/RIF, which was introduced in the second semester of 2012.
results9,655 patients were analyzed, with 44.1% females. HIV testing was conducted in 99.9% of patients, with 82.8% having TB/HIV co-infection. 73.2% of patients had a favorable treatment outcome. No increase was observed in the number of TB patients identified after introduction of Xpert MTB/RIF testing.
conclusionUpon introduction, Xpert testing seemed to have a punctual beneficial effect on TB treatment outcomes, however this effect apparently disappeared shortly afterwards. Challenges remain for integration of TB and HIV care, as worse outcomes are reported for those patients diagnosed with TB shortly after starting ART, and also for those never starting ART. The need of reasonably excluding TB disease before ART start should be highlighted to every health care provider engaged in HIV care.
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